Background: Abdominal aortic aneurysms (AAA) repairs are routine operations with low mortality in the developed world. There are few studies on the operative management of AAA in the Asian population.This study reports the initial results from a unit with no previous experience in this surgery by a single surgeon on completion of training.
Methods: All patients with AAA repair from a prospective database between 1996 and 1999 in the south-east Asian state of Sarawak in Borneo Island were analyzed. Three groups were identified on presentation according to clinical urgency of surgery. Elective surgery was offered to all good risk patients with AAA of >or= 5 cm. All symptomatic patients were offered surgery unless contraindicated medically.
Results: AAA repairs were performed in 69 patients: 32 (46%)had elective repairs of asymptomatic AAA; 20 (29%) had urgent surgery for symptomatic non-ruptured AAA; and 17 (25%)had surgery for ruptured AAA. The mortality rate for elective surgery was 6%; the two deaths occurred early in the series with the subsequent 25 repairs recorded no further mortality. The mortality rates for the urgent, symptomatic non-ruptured AAA repair and ruptured AAA repair were 20% and 35%, respectively. Cardiac and respiratory complications were the main morbidities.Sixty-three patients seen during this period had no surgery; three presented and died of ruptured AAA, 34 had AAA of
Conclusion: This study showed that AAA can be repaired safely by highly motivated and adequately trained surgeons in a hospital with little previous experience.
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http://dx.doi.org/10.1046/j.1445-2197.2003.02668.x | DOI Listing |
Ann Vasc Dis
January 2025
Department of Vascular Surgery, The University of Tokyo, Tokyo, Japan.
The underlying mechanisms of abdominal aortic aneurysms (AAAs) are not fully understood. Given the multifactorial nature of AAA development and progression, a comprehensive approach is essential. Throughout my academic career, I conducted various studies on AAA.
View Article and Find Full Text PDFAnn Vasc Dis
January 2025
Department of Surgery, Eniwa Midorino Clinic, Eniwa, Hokkaido, Japan.
We investigated the association between brachial-ankle pulse wave velocity (PWV) and arterial stiffness and distensibility in the aneurysmal sac of abdominal aortic aneurysm (AAA). Data from 49 patients with AAA from June 2020 to November 2022 at Tokyo Medical University Hospital were retrospectively analyzed. Brachial-ankle PWV (cm/s) was obtained via an automated oscillometric method.
View Article and Find Full Text PDFAnn Vasc Dis
January 2025
Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
The pathophysiological mechanism of abdominal aortic aneurysm (AAA) remains unclear. We previously reported that levels were reduced in the feces of patients with AAA by 16S ribosomal ribonucleic acid (RNA) gene sequencing. In this study, we increased the number of cases and conducted metagenomic analyses to examine bacterial genes associated with the pathophysiology of AAA.
View Article and Find Full Text PDFAnn Vasc Dis
January 2025
Department of Surgery, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Hiroshima, Japan.
Cold agglutinin disease (CAD) is a rare and autoimmune hemolytic disorder caused by the presence of cold-reacting autoantibodies against red blood cells. An abdominal aortic aneurysm (AAA) is a potentially life-threatening condition. This report describes an 83-year-old man with AAA who was diagnosed with primary CAD 9 years before undergoing AAA surgery.
View Article and Find Full Text PDFCancer Genet
January 2025
Department of Chemistry and Biochemistry, The Ohio State University, Marion, USA. Electronic address:
DNA double strand breaks (DSBs) can be generated spontaneously during DNA replication and are repaired primarily by Homologous Recombination (HR). However, efficient repair requires chromatin remodeling to allow the recombination machinery access to the break. TIP60 is a complex conserved from yeast to humans that is required for histone acetylation and modulation of HR activity at DSBs.
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