Purpose: This preliminary study assessed the efficacy of two treatment methods for persistent unilateral or hemispatial neglect following right hemisphere stroke.
Method: Two patients received an intervention focusing on the underlying impairment of attention during visual scanning. Two other participants received an intervention that provided repetitive practice during a functional task of oral reading. Standardized tests of attention and neglect were administered before and after treatment. Performance on a functional task assessing generalization of treatment was probed at every session.
Results: Results indicate no clear conclusions regarding the efficacy of either approach. Factors contributing to these equivocal findings are addressed.
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http://dx.doi.org/10.1310/BWY3-7GQL-596Y-V17J | DOI Listing |
Brain Sci
December 2024
College of Electronic Engineering, Chengdu University of Information Technology, Chengdu 610225, China.
Background: The spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain's gray matter (GM) have been interpreted as representations of neural activity variations. In previous research, white matter (WM) signals, often considered noise, have also been demonstrated to reflect characteristics of functional activity and interactions among different brain regions. Recently, functional gradients have gained significant attention due to their success in characterizing the functional organization of the whole brain.
View Article and Find Full Text PDFAnn Phys Rehabil Med
January 2025
University Grenoble Alpes, UMR CNRS 5105 Neuropsychology and NeuroCognition, CHU Grenoble Alpes, Dept of NeuroRehabilitation South Hospital, Cs 10217-38043 Grenoble cedex 9, France. Electronic address:
Background: Many signs of spatial dysgraphia and drawing errors after right hemispheric stroke (RHS) have been attributed to spatial neglect or impaired sensory feedback. Counterclockwise (contralesional) tilts of graphomotor productions remained to be explained.
Objective: To test whether graphomotor tilts stem from a tilted representation of verticality transposed to the top/bottom axis of the sheet of paper, using data from the DOBRAS cohort.
IBRO Neurosci Rep
June 2025
Rehabilitation Clinic, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Objective: Unilateral spatial neglect (USN) following right hemisphere stroke is more pronounced, severe, and persistent than in the left hemisphere. However, the pathophysiological mechanisms underlying USN remain largely unknown. This study aims to investigate the relationship between the fractional amplitude of low-frequency fluctuations (fALFF) in the right hemisphere of patients with post-stroke USN and the severity of neglect using resting-state functional near-infrared spectroscopy (fNIRS) technology.
View Article and Find Full Text PDFCortex
December 2024
Cognitive Neuroscience, Institute of Neuroscience & Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
The precise cognitive mechanisms underlying spatial neglect are not fully understood. Recent studies have provided the first evidence for aberrant behavioral and electrophysiological prediction and prediction error responses in patients with neglect, but also in right-hemispheric (RH) stroke patients without neglect. For prediction-dependent attention, as assessed with Posner-type cueing paradigms with volatile cue-target contingencies, studies in healthy volunteers point to a crucial role of the right temporo-parietal junction (rTPJ) - as part of a network commonly disrupted in neglect.
View Article and Find Full Text PDFNeurol Res Pract
January 2025
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Background: Apraxia is a motor-cognitive disorder that primary sensorimotor deficits cannot solely explain. Previous research in stroke patients has focused on damage to the fronto-parietal praxis networks in the left hemisphere (LH) as the cause of apraxic deficits. In contrast, the potential role of the (left) primary motor cortex (M1) has largely been neglected.
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