There is a severe shortage of affordable antivenoms and antitoxins in the developing world. An anti-digoxin antitoxin for oleander poisoning was introduced in Sri Lanka in July, 2001, but because of its cost, stocks ran out in July, 2002. We looked at the effect of its introduction and withdrawal on case fatality, and determined its cost-effectiveness. The antitoxin strikingly reduced the case fatality; its absence resulted in a three-fold rise in deaths. At the present price of US2650 dollars per course, every life saved cost 10209 dollars and every life year cost 248 dollars. Reduction of the antitoxin's price to 400 dollars would reduce costs to 1137 dollars per life gained; a further reduction to 103 dollars would save money for every life gained. Treatments for poisoning and envenoming should be included in the present campaign to increase availability of affordable treatments in the developing world.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/s0140-6736(03)14415-7 | DOI Listing |
Curr Drug Saf
January 2025
Topiwala National Medical College & BYL Nair Charitable Hospital, Clinical Pharmacology, India.
Introduction: This case study presents a rare and fatal instance of Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome in a 51-year-old male patient diagnosed with Rheumatoid Arthritis (RA).
Case Presentation: The patient was initially treated with sulfasalazine, leflunomide, and hydroxychloroquine, following which he developed a rash, fever, and loose stools. Drug allergy was suspected, and the antirheumatic medications were withdrawn, following which, the patient improved.
J Educ Health Promot
November 2024
Department of Community and Family Medicine, AIIMS, Deoghar, Jharkhand, India.
Background: The Andaman and Nicobar Islands reported the first coronavirus disease 2019 (COVID-19) case on March 26, 2020. This study aimed to describe the epidemiological and clinical profiles of COVID-19 mortality that occurred during the first and second waves of COVID-19 pandemic and to compare the differences between them.
Materials And Methods: This was a retrospective cohort study carried out among COVID-19 patients admitted at GB Pant Hospital, Port Blair.
Urol Case Rep
January 2025
Consultant of Endourology and MIS at King Fahad Hospital of University, College of Medicine Imam Abdulrahman bin Faisal University, Saudi Arabia.
Spontaneous, non-traumatic bleeding into the subcapsular and perirenal space is a rare and potentially fatal condition known as Wunderlich syndrome (WS). It has a variety of causes including the usage of anticoagulation. Many anticoagulants including warfarin can interact with other medication and lead to potentially fatal complications, Herein, we report a case of a 47 year old female on warfarin who developed subcapsular renal hematoma and retroperitoneal hematoma after the completion of ciprofloxacin treatment course.
View Article and Find Full Text PDFJ Immunother Precis Oncol
February 2025
Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Thrombotic thrombocytopenic purpura (TTP) is characterized by thrombotic microangiopathy resulting from decreased activation of the von Willebrand factor-cleaving protease (ADAMTS13). TTP can cause organ damage and is often fatal if the appropriate treatment is not started immediately. Although primary immune TTP is the most common form of TTP, secondary immune etiologies, including complications from immune checkpoint inhibitors (ICIs), have also been reported.
View Article and Find Full Text PDFCureus
December 2024
Infectious Diseases, Hospital Sultanah Aminah, Johor Bahru, MYS.
Mycotic aneurysms are rare but severe complications that can arise from systemic bacterial infections, including those caused by Salmonella species. These aneurysms can progress rapidly and are associated with high mortality. A 62-year-old man with poorly controlled type 2 diabetes mellitus presented to the hospital in septic shock.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!