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Convenient indole synthesis from 2-iodoanilines and terminal alkynes by the sequential Sonogashira reaction and the cyclization reaction promoted by tetrabutylammonium fluoride (TBAF). | LitMetric
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Convenient indole synthesis from 2-iodoanilines and terminal alkynes by the sequential Sonogashira reaction and the cyclization reaction promoted by tetrabutylammonium fluoride (TBAF).

Naoyuki Suzuki Sakura Yasaki Akito Yasuhara Takao Sakamoto

Chem Pharm Bull (Tokyo)

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Published: October 2003

The sequential Sonogashira reaction and the cyclization reaction of various 2-iodoanilines and terminal alkynes in the presence of a palladium catalyst and tetrabutylammonium fluoride (TBAF) gave the corresponding 2-substituted indoles in good yields.

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http://dx.doi.org/10.1248/cpb.51.1170DOI Listing

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