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Myotonia Congenita in Australian Merino Sheep with a Missense Variant in .
Animals (Basel)
December 2024
Sydney School of Veterinary Science, The University of Sydney, Camden, NSW 2570, Australia.
Myotonia congenita is a hereditary, non-dystrophic skeletal muscle disorder associated with muscle stiffness due to delayed muscle relaxation after contraction. We review myotonia congenita in domesticated animals and humans and investigated suspected myotonia congenita in a flock of Merino sheep in Australia. In 2020, a property in New South Wales reported a four-year history of lambs that would fall on disturbance before rapidly recovering, with 13 affected sheep identified in 2020.
View Article and Find Full Text PDFConsumers' self-reported adherence to directions for non-prescription medicines and the role of risk perception.
Res Social Adm Pharm
November 2022
School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia. Electronic address:
Background: Non-prescription medicines (NPMs), while relatively safe, are responsible for a small but significant proportion of medication misadventure and inappropriate use may lead to avoidable healthcare cost. Some consumers vary their use of NPMs from the directions provided on packaging or advice from healthcare professionals. Consumers may use NPMs at lower doses or less frequently than directed because of the risk of side effects.
View Article and Find Full Text PDFDrug-drug interaction database for safe prescribing of systemic antifungal agents.
Ther Adv Infect Dis
April 2021
Manchester Fungal Infection Group, The University of Manchester, Manchester, UK.
Introduction: A drug-drug interaction (DDI) describes the influence of one drug upon another or the change in a drug's effect on the body when the drug is taken together with a second drug. A DDI can delay, decrease or enhance absorption or metabolism of either drug. Several antifungal agents have a large number of potentially deleterious DDIs.
View Article and Find Full Text PDFRecognizing and Managing Polypharmacy in Advanced Illness.
Med Clin North Am
May 2020
Advanced Post-Graduate Education in Palliative Care, Online Master of Science in Palliative Care, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy Baltimore, 20 North Pine Street, S405, Baltimore, MD 21201, USA. Electronic address:
Older adults, particularly those late in life, are at higher risk for medication misadventure, yet bear the burden of increasing polypharmacy. It is incumbent on practitioners who care for this vulnerable population to use one or more approaches to deprescribe medications that impose a greater burden than benefit, including medically futile medications. It is essential that health care providers use compassionate communication skills when explaining these interventions with patients and families, pointing out that this is a positive, patient-centric intervention.
View Article and Find Full Text PDFMedia Representations of Breech Birth: A Prospective Analysis of Web-Based News Reports.
J Midwifery Womens Health
July 2017
Introduction: Recent research has demonstrated that the media presentation of childbirth is highly medicalized, often portraying birth as risky and dramatic. Media representation of breech presentation and birth is unexplored in this context. This study aimed to explore the content and tone of news media reports relating to breech presentation and breech birth.
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