Aim: To establish 3D QSAR model of propenamides with anti-malarial activities.
Methods: Chemical synthesis combined with comparative molecular field analysis (CoMFA).
Results: Generated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6).
Conclusion: The activity of anti-W2 depends mostly on steric interaction and the activity of anti-D6 depends on both steric and electrostatic interaction.
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View Article and Find Full Text PDFSynthesis of propenamides with anti-malarial activities and 3D-QSAR study.
Yao Xue Xue Bao
July 2003
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Aim: To establish 3D QSAR model of propenamides with anti-malarial activities.
Methods: Chemical synthesis combined with comparative molecular field analysis (CoMFA).
Results: Generated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6).
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