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Characterization of Human CD8αβ Interaction With Classical and Unconventional MHC Molecules.
Eur J Immunol
December 2024
Immunocore Limited, Abingdon, Oxon, UK.
The CD8 co-receptor exists as both an αα homodimer, expressed on subsets of specialized lymphoid cells, and as an αβ heterodimer, which is the canonical co-receptor on cytotoxic T-cells, tuning TCR thymic selection and antigen-reactivity in the periphery. However, the biophysical parameters governing human CD8αβ interactions with classical MHC class I (MHCI) and unconventional MHC-like molecules have not been determined. Using hetero-dimerized Fc-fusions to generate soluble human CD8αβ, we demonstrate similar weak binding affinity to multiple different MHCI alleles compared with CD8αα.
View Article and Find Full Text PDFEvaluation of CD1a immunostaining in the diagnosis of cutaneous leishmaniasis caused by in Sri Lanka.
Parasitology
November 2024
Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease, routinely diagnosed by direct light microscopy. The sensitivity of this method is dependent on the number of parasites present in the lesion. Immunoexpression of CD1a surface antigen by amastigotes and its application as a diagnostic tool has been recently demonstrated in several species including , and .
View Article and Find Full Text PDFNew insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells.
Cancer Immunol Immunother
November 2024
Associate Laboratory i4HB, NOVA School of Science and Technology, Institute for Health and Bioeconomy, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal.
Sialic acids at the cell surface of dendritic cells (DCs) play an important immunomodulatory role, and their manipulation enhances DC maturation, leading to heightened T cell activation. Particularly, at the molecular level, the increased stability of surface MHC-I molecules in monocyte-derived DCs (MoDCs) underpins an improved DC: T cell interaction. In this study, we focused on the impact of sialic acid remodelling by treatment with Clostridium perfringens sialidase on MoDCs' phenotypic and functional characteristics.
View Article and Find Full Text PDFLangerhans cell histiocytosis in an infant.
Pediatr Pulmonol
October 2024
Department of Gastroenterology and Pediatric Endoscopy Center, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
A 2-month-old male infant presented with a persistent mild cough and a pink papule beneath the left eyelid. Imaging studies revealed diffuse lung opacities and a cystic shadow in the right middle lobe, with no evidence of bacterial or fungal infection. Skin biopsy demonstrated positive immunohistochemical staining for CD207/Langerin and CD1a, leading to a diagnosis of Langerhans-cell histiocytosis (LCH).
View Article and Find Full Text PDFEvaluating CD1a Immunohistochemistry for Tegumentary Leishmaniasis Diagnosis in the New World: A Focus on Colombia.
Am J Dermatopathol
October 2024
Instituto Colombiano de Medicina Tropical- Universidad CES, Medellín, Colombia.
Introduction: Leishmaniasis, a chronic vector-borne disease caused by parasites of the genus Leishmania, presents diagnostic challenges. Conventional diagnostic methods struggle with accurate visualization of these parasites. Immunostaining with CD1a has demonstrated effectiveness in visualizing Leishmania parasites, particularly in the Old World.
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