In the past 2 years, intranasal nebulized medications have emerged as a widely prescribed treatment for medical management of chronic rhinosinusitis. This represents an innovative and advanced approach to treating acute exacerbations of chronic rhinosinusitis topically. The use of specially formulated medication compounds delivered by unique nebulization equipment is reviewed in the treatment of patients with chronic sinus disease. Scientific data including related upper and lower respiratory literature is included, as well as the important aspects of factors affecting nebulized medication delivery to the sinuses. The benefits, effectiveness, risks, and adverse effects of intranasal nebulized medications are also addressed. A treatment algorithm identifying appropriate use of nebulized medications in the treatment plan for chronic sinusitis patients is then presented in diagrammatic format.
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