The masking effect of three types of music and white masking noise upon special audiometric tests was determined in laboratory c. The stimulus-noise (S/N) ratio was found to be the most considerable factor influencing oral information processing in spite of the type of music or noise used as a masking agent. All types of music (modern, classic or modern music records in backwards order) showed no significant differences in masking being in the same way stronger maskers as white noise. Some conclusions are made concerning hygienic and ergonomic aspects of the problem.
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BMC Complement Med Ther
January 2025
Division of Pharmacology and Biopharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand.
Background: Plant flavonoids such as quercetin are useful for both the therapeutic and preventive care of a variety of illnesses. Nevertheless, their antitumor efficacy against KON oral cancer is still unknown. Therefore, the aim of this investigation was to examine quercetin's anti-growth, anti-migrative, and anti-invasive characteristics.
View Article and Find Full Text PDFBMC Med Educ
January 2025
Department of Nursing, Tabriz Islamic Azad University of Medical Sciences, Tabriz, Iran.
Background: An appropriate clinical environment by providing learning opportunities, plays an important role in preparing students to apply the knowledge learned at the bedside. Since the lived experiences of patients in the clinical environment are effective on the quality of student's learning, the present study was conducted with the aim of explaining the lived experiences of patients regarding bedside teaching.
Materials And Methods: The present qualitative study was conducted using a content analysis approach in 2023 at the Imam Sajjad educational and therapeutic center affiliated with Tabriz Islamic Azad University of Medical Sciences.
Head Neck Pathol
January 2025
Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Bairro Areão, Piracicaba, São Paulo, Brazil.
Introduction: Solitary fibrous tumor (SFT) is a fibroblastic neoplasm of uncertain biological origin that is rare in the tongue.
Case Report: A 42-year-old woman presented with a painless, submucosal nodule in the tongue. Based on the clinical hypothesis of benign mesenchymal neoplasia, the lesion was excised, and the specimen was submitted for histopathological analysis.
Drug Metab Dispos
January 2025
Department of Pharmaceutics, University of Washington, Seattle, Washington. Electronic address:
Physiologically based pharmacokinetic (PBPK) modeling is a physiologically relevant approach that integrates drug-specific and system parameters to generate pharmacokinetic predictions for target populations. It has gained immense popularity for drug-drug interaction, organ impairment, and special population studies over the past 2 decades. However, an application of PBPK modeling with great potential remains rather overlooked-prediction of diarrheal disease impact on oral drug pharmacokinetics.
View Article and Find Full Text PDFDrug Metab Dispos
January 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington. Electronic address:
To further the development of an in vitro model that faithfully recapitulates drug disposition of orally administered drugs, we investigated the utility of human enteroid monolayers to simultaneously assess intestinal drug absorption and first-pass metabolism processes. We cultured human enteroid monolayers from 3 donors, derived via biopsies containing duodenal stem cells that were propagated and then differentiated atop permeable Transwell inserts, and confirmed transformation into a largely enterocyte population via RNA sequencing analysis and immunocytochemistry (ICC) assays. Proper cell morphology was assessed and confirmed via bright field microscopy and ICC imaging of tight junction proteins and other apically and basolaterally localized proteins.
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