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Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels. | LitMetric
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Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels.

Marian Beekman Bastiaan T Heijmans Nicholas G Martin John B Whitfield Nancy L Pedersen Ulf DeFaire Harold Snieder Nico Lakenberg Peter de Knijff Rune R Frants Gert Jan B van Ommen Cornelis Kluft George P Vogler P Eline Slagboom Dorret I Boomsma

Twin Res

Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Published: August 2003

Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

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http://dx.doi.org/10.1375/136905203322296692DOI Listing

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