AI Article Synopsis
- * The researchers utilized a bioassay using mouse hepatoma cells to isolate and evaluate the compounds based on their ability to induce quinone reductase (QR), a potential indicator of cancer chemopreventive properties.
Article Abstract
A new butenylflavanone, (2S)-5-hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone (1), and a new rotenoid, 4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin (2), as well as three active flavonoids of previously known structure, isoliquiritigenin (3), genistein (4), and chrysoeriol (5), along with nine known inactive compounds, alpha-toxicarol (6), sumatrol, 6a,12a-dehydro-alpha-toxicarol, 11-hydroxytephrosin, obovatin, marmesin, lupenone, benzyl benzoate, and benzyl trans-cinnamate, were isolated from an ethyl acetate-soluble extract of the stems of Tephrosia toxicaria, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells to monitor chromatographic fractionation. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. All isolates were evaluated for their potential cancer chemopreventive properties utilizing an in vitro assay to determine quinone reductase induction. Selected compounds were tested in a mouse mammary organ culture assay to evaluate the inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced preneoplastic lesions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np0302100 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A new β-hydroxydihydrochalcone from Tephrosia uniflora, and the revision of three β-hydroxydihydrochalcones to flavanones.
Fitoterapia
April 2022
Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya. Electronic address:
Article Synopsis
- The CHCl/MeOH extract from Tephrosia uniflora stems produced a new compound called (S)-elatadihydrochalcone-2'-methyl ether along with three known compounds: elongatin, (S)-elatadihydrochalcone, and tephrosin.
- Elongatin exhibited moderate antibacterial effects against Bacillus subtilis and showed toxicity against MCF-7 human breast cancer cells.
- The study suggests revising the structures of three β-hydroxydihydrochalcones to flavanones based on comparisons of literature and experimental NMR data.
Rotenone: from modelling to implication in Parkinson's disease.
Folia Neuropathol
July 2020
Department for Biomedical Sciences, Institute of Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria.
Rotenone ([2R-(2α,6aα,12aα)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyran[3,4-b]furo [2,3-h][1]benzopyran-6(6aH)-one) is a naturally occurring compound derived from the roots and stems of Derris, Tephrosia, Lonchocarpus and Mundulea plant species. Since its discovery at the end of the 19th century, rotenone has been widely used as a pesticide for controlling insects, ticks and lice, and as a piscicide for management of nuisance fish in lakes and reservoirs. In 2000, Betarbet et al.
View Article and Find Full Text PDFFour Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya.
Molecules
September 2017
Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya.
Four new flavones with modified prenyl groups, namely ()-5-hydroxytephrostachin (), purleptone (), ()-5-hydroxyanhydrotephrostachin (), and terpurlepflavone (), along with seven known compounds (-), were isolated from the CH₂Cl₂/MeOH (1:1) extract of the stem of subsp. , a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence.
View Article and Find Full Text PDFPhylogenetic Diversity and Antifungal Activity of Endophytic Fungi Associated with Tephrosia purpurea.
Mycobiology
December 2015
Hunan Provincial Engineering & Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China.; National Research Center of Engineering & Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China.
Sixty-one endophytic fungus strains with different colony morphologies were isolated from the leaves, stems and roots of Tephrosia purpurea with colonization rates of 66.95%, 37.50%, and 26.
View Article and Find Full Text PDFIn Vitro effect of the ethanolic extract of Tephrosia Vogelii on Rhipicephalus Sanguineus in Abomey-Calavi.
Avicenna J Phytomed
June 2015
Research Laboratory in Applied Biology , Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01BP2009 Abomey-Calavi, Republic of Benin.
Objectives: Ticks are vectors of several diseases, of which many are zoonosis transmissible to humans. The use of Tephrosia leafs' extract as a low cost acaricide is spreading among farmers in central Kenya.
Materials And Methods: The present study's aim is to inventory endogenous control methods against dogs' ticks among which Rhipicephalus sanguineus, in the Municipality of Abomey-Calavi.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!