DNA nanomotor using duplex-quadruplex conformational transition.

Nucleic Acids Res Suppl

Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan.

Published: October 2003

For DNA nanomotor, we synthesized 8-Py-dG and incorporated it into d(T3G2)4 which can form quadruplex. We measured CD spectra for this ODN. The result suggested that this ODN was changed from quadruplex to duplex by the hybridization with the complementary strand. Further, this ODN had a very interesting property of fluorescence. The fluorescent intensity could be controlled whether the complementary strand was existed, or not.

Download full-text PDF

Source
http://dx.doi.org/10.1093/nass/3.1.161DOI Listing

Publication Analysis

Top Keywords

dna nanomotor
8
complementary strand
8
nanomotor duplex-quadruplex
4
duplex-quadruplex conformational
4
conformational transition
4
transition dna
4
nanomotor synthesized
4
synthesized 8-py-dg
4
8-py-dg incorporated
4
incorporated dt3g24
4

Similar Publications

The therapeutic outcomes of medications were restricted by the colonic mucosal barrier during the treatment of colorectal cancer (CRC). Micro/nanomotors can overcome the mucus barriers to reach deep colorectal tumors. In this study, we constructed a novel microsized PLGA-Pt micromotor (MM) driven by hydrogen peroxide (HO) to enhance drug delivery to the CRC tissues and achieve effective antitumor therapy.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on enhancing the immune response against breast cancer by addressing the limitations of current therapies that utilize the cGAS-STING pathway and PD-1/PD-L1 checkpoint blockade.
  • A novel silica nanomotor is created, which utilizes a unique design for better penetration into cancer cells and is equipped with a photosensitizer to activate the cGAS-STING pathway and boost immune cell maturation.
  • Asymmetrical modifications on the nanomotor enable both movement and targeted intervention, effectively blocking PD-1/PD-L1 interactions to improve T cell responses, offering a new approach for targeted breast cancer therapy.
View Article and Find Full Text PDF

Spherical DNA Nanomotors Enable Ultrasensitive Detection of Active Enzymes in Extracellular Vesicles for Cancer Diagnosis.

Angew Chem Int Ed Engl

January 2025

Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing, 100190, China.

Enzymes encapsulated in extracellular vesicles (EVs) hold promise as biomarkers for early cancer diagnosis. However, precise measurement of their catalytic activities within EVs remains a notable challenge. Here, we report an enzymatically triggered spherical DNA nanomotor (EDM) that enables one-pot, cascaded, and highly sensitive analysis of the activity of EV-associated or free apurinic/apyrimidinic endonuclease 1 (APE1, a key enzyme in base excision repair) across various biological samples.

View Article and Find Full Text PDF

Electroosmotic Flow-Driven DNA-CNT Nanomotor via Tunable Surface-Charged Nanopore Array.

J Phys Chem Lett

November 2024

Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing 211100, China.

Nanomotors are usually designed to work in liquid media and carry cargo; they exhibit excellent potential for biosensing and disease treatment applications due to their small size. Graphene and carbon nanotubes (CNTs) are crucial components of rotary nanomotors because of excellent mechanical properties and adaptability to the human body. Herein, we introduce a DNA-CNT-based nanomotor that achieves its rotational control through an array of nanopores with tunable surface charges.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers have developed dual-responsive MnO-loaded carbonaceous nanobottle motors (MnO NBMs) that can move in response to different stimuli, enhancing motion control for various applications.* -
  • These nanomotors are combined with functional nanoparticles and hairpin DNA to create swimming functional MnO NBMs for improved targeting of miRNA, which is crucial for biological sensing.* -
  • The integration of these nanomotors with photoelectrochemical biosensors allows for sensitive and rapid detection of microRNA-155, demonstrating effective automation and potential for practical use in cancer diagnostics.*
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!