For DNA nanomotor, we synthesized 8-Py-dG and incorporated it into d(T3G2)4 which can form quadruplex. We measured CD spectra for this ODN. The result suggested that this ODN was changed from quadruplex to duplex by the hybridization with the complementary strand. Further, this ODN had a very interesting property of fluorescence. The fluorescent intensity could be controlled whether the complementary strand was existed, or not.
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http://dx.doi.org/10.1093/nass/3.1.161 | DOI Listing |
Int J Pharm
January 2025
Clinical Center for Tumor Therapy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address:
The therapeutic outcomes of medications were restricted by the colonic mucosal barrier during the treatment of colorectal cancer (CRC). Micro/nanomotors can overcome the mucus barriers to reach deep colorectal tumors. In this study, we constructed a novel microsized PLGA-Pt micromotor (MM) driven by hydrogen peroxide (HO) to enhance drug delivery to the CRC tissues and achieve effective antitumor therapy.
View Article and Find Full Text PDFTalanta
March 2025
School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. Electronic address:
Angew Chem Int Ed Engl
January 2025
Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing, 100190, China.
Enzymes encapsulated in extracellular vesicles (EVs) hold promise as biomarkers for early cancer diagnosis. However, precise measurement of their catalytic activities within EVs remains a notable challenge. Here, we report an enzymatically triggered spherical DNA nanomotor (EDM) that enables one-pot, cascaded, and highly sensitive analysis of the activity of EV-associated or free apurinic/apyrimidinic endonuclease 1 (APE1, a key enzyme in base excision repair) across various biological samples.
View Article and Find Full Text PDFJ Phys Chem Lett
November 2024
Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing 211100, China.
Nanomotors are usually designed to work in liquid media and carry cargo; they exhibit excellent potential for biosensing and disease treatment applications due to their small size. Graphene and carbon nanotubes (CNTs) are crucial components of rotary nanomotors because of excellent mechanical properties and adaptability to the human body. Herein, we introduce a DNA-CNT-based nanomotor that achieves its rotational control through an array of nanopores with tunable surface charges.
View Article and Find Full Text PDFSmall
September 2024
School of Chemical Engineering & Technology, China University of Mining and Technology, Xuzhou, Jiangsu, 221116, P. R. China.
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