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Current developments in T-cell receptor therapy for Acute Myeloid Leukaemia.
Blood Adv
January 2025
The University of Sydney, Sydney, Australia.
T-cell receptor (TCR) therapies are a promising modality for the treatment of cancers, with significant efforts being directed towards acute myeloid leukaemia (AML), a particularly challenging disease. Chimeric antigen receptor (CAR) T-cells targeting single surface antigens have shown remarkable efficacy for B-cell lymphoblastic leukaemia, lymphomas and multiple myeloma. However, AML presents formidable obstacles to the effectiveness of CAR T-cells due to the widespread expression of heterogenous leukaemia immunophenotypes and surface antigen targets additionally present on normal myeloid cells.
View Article and Find Full Text PDFMaternal characteristics and their relation to early mother-child interaction and cognitive development in toddlers.
PLoS One
January 2025
Department of Psychology, Laboratory for Sleep, Cognition and Consciousness Research, University of Salzburg, Salzburg, Austria.
Early mother-infant interaction is believed to have a significant impact on the social, cognitive, and emotional development of children. These interactions are not only influenced by child and contextual factors but also by the mother's personality traits and strain. In this study, we investigated the relation between maternal factors such as personality, depressive symptoms, or experiencing of emotions, and (i) children's early cognitive development and (ii) interaction patterns in a sample of 116 mother-child dyads (mean child age = 18.
View Article and Find Full Text PDFCorrection: Attitudes of Health and Mental Health Professionals, and Police Staff towards Mentally Ill Offenders in Greece.
Community Ment Health J
January 2025
Lab of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.
Endoscopic ultrasound-guided biopsy of healthy pig pancreas - Towards the histological diagnosis of chronic pancreatitis.
Rev Esp Enferm Dig
September 2024
Gastroenterology, Hospital Clínico Universitario de Santiago.
Background: diagnosis of early chronic pancreatitis (CP) is a challenge due to the lack of accurate methods. The ability of endoscopic ultrasound (EUS) guided biopsy to obtain pancreatic core tissue samples in patients with minimal changes of CP and its potential use for the histological diagnosis of early CP are unknown. The aim of the study was to evaluate the ability of different EUS-guided biopsy core needles to obtain histological samples of healthy pig pancreas.
View Article and Find Full Text PDFTerritorial obstacles causing early school dropout in Morocco: Multivariate spatial analysis.
Heliyon
January 2025
Laboratory of Social and Solidarity Economy Governance and Development (LARESSGD), Department of Economics, Faculty of Law Economics and Social Sciences, Cadi Ayyad University, Marrakech, Morocco.
Early school dropout rates in Morocco exhibit widespread spatial imbalances leading to adverse consequences. Indeed, there is thus a pressing need to investigate the factors contributing to the phenomenon. To this end, this study conducts a multivariate spatial analysis of 75 provinces in Morocco.
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