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Sex differences in gut microbiota, hypertension, and cardiovascular risk.
Eur J Pharmacol
January 2025
Center for Hypertension and Precision Medicine, Microbiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, OH, USA. Electronic address:
The intricate ecosystem of the gut microbiome exhibits sex-specific differences, influencing the susceptibility to cardiovascular diseases (CVD). Imbalance within the gut microbiome compromises the gut barrier, activates inflammatory pathways, and alters the production of metabolites, all of which initiate chronic diseases including CVD. In particular, the interplay between lifestyle choices, hormonal changes, and metabolic byproducts uniquely affects sex-specific gut microbiomes, potentially shaping the risk profiles for hypertension and CVD differently in men and women.
View Article and Find Full Text PDFBioarchaeological Perspectives on Late Antiquity in Dalmatia: Paleogenetic, Dietary, and Population Studies of the Hvar - Radošević burial site.
Archaeol Anthropol Sci
September 2024
Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
Article Synopsis
- The Late Antique burial site of Hvar - Radošević on the Croatian island of Hvar provides insights into a diverse population influenced by political unrest in the Roman Empire during the 3rd to 5th centuries CE.
- Genetic analysis shows a range of ancestries linked to trade routes, highlighting the area's genetic variability.
- Dietary assessments reveal a primarily terrestrial diet with signs of poor living conditions, including high childhood mortality and health issues, while burial practices show no significant social distinctions among the deceased.
β-Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta.
Med Res Rev
November 2024
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
At different stages of life, from embryonic to postnatal, varying oxygen concentrations modulate cellular gene expression by enhancing or repressing hypoxia-inducible transcription factors. During embryonic/fetal life, these genes encode proteins involved in adapting to a low-oxygen environment, including the induction of specific enzymes related to glycolytic metabolism, erythropoiesis, angiogenesis, and vasculogenesis. However, oxygen concentrations fluctuate during intrauterine life, enabling the induction of tissue-specific differentiation processes.
View Article and Find Full Text PDFEmotional Suffering After the COVID-19 Pandemic: Grieving the Loss of Family Members in Brazil.
Int J Environ Res Public Health
October 2024
Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-900, São Paulo, Brazil.
(1) Background: Brazil has been severely affected by the COVID-19 pandemic, with over 700,000 deaths and, consequently, a drastic increase in the number of bereaved individuals. This study aims to understand the emotional suffering after the COVID-19 pandemic in Brazilian adults whose family members have died due to COVID-19. (2) Methods: A clinical-qualitative, cross-sectional, descriptive-exploratory study with a sample composed of 10 bereaved family members was used.
View Article and Find Full Text PDFInnovative Diagnostic Solutions in Hemostasis.
Diagnostics (Basel)
November 2024
Haematology Department, Institute of Clinical Pathology and Medical Research (ICPMR), Sydney Centres for Thrombosis and Haemostasis, Westmead Hospital, Westmead, NSW 2145, Australia.
Hemostasis describes the process of blood clotting homeostasis. Hemostasis reflects a balance of procoagulant and anticoagulant mechanisms that aim to prevent both bleeding and thrombosis. If hemostasis is disrupted, and bleeding or thrombosis occur, then laboratory testing may ensue to either diagnose the reason for bleeding or thrombosis, or to manage patients under therapy or treatment for bleeding or thrombosis.
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