AI Article Synopsis
- Researchers studied the effectiveness of chiral Lewis acids in promoting highly enantioselective intramolecular carbonyl ene reactions for unsaturated alpha-keto esters.
- Using chiral Lewis acids like [Sc((R,R)-Ph-pybox)](OTf)(3) and [Cu((S,S)-Ph-box)](OTf)(2), they achieved notable reactions at room temperature in CH(2)Cl(2).
- The outcome was the production of monocyclic compounds with good yields and excellent enantioselectivity, highlighting the potential for these catalysts in organic synthesis.
Article Abstract
[reaction: see text] Chiral Lewis acid-promoted highly enantioselective intramolecular carbonyl ene reactions of unsaturated alpha-keto esters have been investigated. In the presence of chiral Lewis acids such as [Sc((R,R)-Ph-pybox)](OTf)(3) and [Cu((S,S)-Ph-box)](OTf)(2), several unsaturated alpha-keto esters underwent carbonyl ene reactions in CH(2)Cl(2) at room temperature to give monocyclic products in good yield and excellent enantioselectivity.
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| http://dx.doi.org/10.1021/ol035486d | DOI Listing |
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