Despite its principal mechanical function in the storage and release of urine, the biomechanical properties of the urethra have remained largely unexplored. The purpose of this study was to develop and validate an experimental model that can be used for evaluating whole urethral tissue in such a manner. Bladder-urethral specimens were excised from halothane-anesthetized female rats and mounted at in vivo length within the experimental apparatus consisting of a tissue perfusion chamber, an adjustable fluid column, and a laser micrometer. Outer diameter measurements were made at proximal, mid, and distal axial locations in response to increases in intraluminal pressure and after addition of various muscle-responsive agents. Basal smooth muscle tone and regional variations in compliance were detected through pressure-diameter responses. Chemically evoked contractile responses were measured and correspond to regional compositions of intrinsic smooth and striated muscle components. The results presented illustrate the utility of this system, which should permit a more thorough characterization of structure-function relationships and urethral biomechanical function in relation to normal and dysfunctional tissue states.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1152/ajprenal.00126.2003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Two Decellularization Protocols on the Mechanical Behavior and Structural Properties of the Human Urethra.
Int J Mol Sci
November 2024
National Institute of Rheumatic Diseases, Nabr. I. Krasku 4, 921 12 Piestany, Slovakia.
Article Synopsis
- - The study compares two decellularization methods (enzyme-detergent and detergent-detergent) to see how they affect the structure and mechanics of human urethral tissue, using samples from 18 individuals.
- - Both methods successfully removed cellular content while maintaining essential extracellular matrix components like collagen and elastic fibers, indicating they preserved the tissue's structural integrity.
- - Biomechanical tests showed that the detergent-detergent method resulted in lower stress levels compared to native tissues, and both methods had reduced elasticity, but none were toxic to stem cells, suggesting they are viable for tissue engineering and biobanking.
Can We Differentiate Between Organic and Functional Bladder Outlet Obstruction in Males With Parkinson's Disease?
Neurourol Urodyn
January 2025
Urology Department, Hospital Clínico San Carlos, Universidad complutense, Madrid, Spain.
Article Synopsis
- The study aimed to identify the type of bladder outlet obstruction (BOO) in patients with Parkinson's disease (PD) by comparing them to patients with benign prostatic hyperplasia (BPH).
- It involved 46 patients split into two groups, with tests conducted to analyze their bladder function and determine the Dynamic Urethral Resistance Relationship (DURR) patterns, categorizing them into functional or organic obstruction types.
- Results showed that a majority (70%) of PD patients exhibited functional obstruction (DURR pattern A) compared to only 4% in the BPH group, indicating that most PD patients experience functional BOO.
Microenergy shockwave therapies for female stress urinary incontinence.
Transl Androl Urol
August 2024
Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.
Article Synopsis
- Research into regenerative therapies, such as stem cell injections and microenergy treatments, shows promise but needs more investigation before they can be widely implemented.
- Low-intensity extracorporeal shockwave therapy (Li-ESWT) and microenergy acoustic pulse (MAP) therapy have shown potential in preclinical studies for improving urinary continence by regenerating pelvic floor muscles and enhancing cellular functions, though further studies are essential to determine their long-term safety and effectiveness.
Comparison of the Vaginal and Labial Dimensions of Ethnic Chinese and Western Nullipara.
Int Urogynecol J
September 2024
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, 48109, USA.
Introduction And Hypothesis: Vaginal dimensions have clinical and surgical implications. We sought to quantify the differences between vaginal and labial dimensions in healthy ethnic Chinese and Western women with normal pelvic organ support.
Methods: This is a cross-sectional study of a convenience sample of ethnic Chinese nulliparas (n = 33) and Western nulliparas (n = 33) recruited for research purposes.
Polish Society of Biomechanics Morecki&Fidelus Award Winner: Comparison of two polymers PDO and PLLA/PCL in application of urological stent for the treatment of male urethral stenosis.
Acta Bioeng Biomech
June 2024
1Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Mechanical Engineering, University of Zielona Góra, Poland.
: The primary objective of the conducted research was to develop an urological stent design for the treatment of male ure-thral stenosis. Given the variable loading conditions inside the urethra, the proposed stent should maintain normal tissue kinetics and obstruct the narrowed lumen. The suitable selection for the stent material significantly influences the regeneration and proper remodeling of the urethral tissues.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!