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PCR and restriction endonuclease assay for detection of a novel mutation associated with sulfonamide resistance in Neisseria meningitidis. | LitMetric

PCR and restriction endonuclease assay for detection of a novel mutation associated with sulfonamide resistance in Neisseria meningitidis.

Antimicrob Agents Chemother

Epidemiology and Molecular Biology Unit, The Children's University Hospital. Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland.

Published: October 2003

We identified a previously undocumented mutation in the dihydropteroate synthase (folP) gene associated with Neisseria meningitidis sulfonamide resistance. A PCR-based assay to detect this mutation, which is 100% predictive of sulfonamide resistance, was developed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201121PMC
http://dx.doi.org/10.1128/AAC.47.10.3336-3338.2003DOI Listing

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