The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(03)00789-3 | DOI Listing |
Publication Analysis
Top Keywords
hcmv protease
8
pyrimido[12-b]-1245-tetrazin-6-ones hcmv
4
protease inhibitors
4
inhibitors class
4
class heterocycles
4
heterocycles flavin-like
4
flavin-like redox
4
redox properties
4
properties synthesis
4
synthesis biological
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!