AI Article Synopsis
- Chrysene-linked pyrrolobenzodiazepine hybrids have been developed, demonstrating cytotoxic effects on certain cancer cell lines.
- These compounds show strong DNA-binding affinity, which is crucial for their potential effectiveness as cancer treatments.
- Molecular modeling studies support the findings, indicating a reliable approach to understanding how these compounds interact with DNA.
Article Abstract
Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that possess cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.
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| http://dx.doi.org/10.1016/s0960-894x(03)00743-1 | DOI Listing |
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