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Supramolecular Chiral Assembly of Dendritic Amphiphiles in Aqueous Media.
Chemistry
November 2024
International Joint Laboratory of Biomimetic & Smart Polymers, School of Materials Science and Engineering, Shanghai University, Mailbox 152, Shangda Rd. 99, Shanghai, 200444, China.
Dendritic amphiphiles are a promising class of topological blocks for self-assembly to construct chiral supramolecular aggregates in aqueous media. Their unique dendritic geometry, structure variability and multivalence can mediate the assemblies with versatile morphologies and functions. The bulky dendritic moieties also enable the appropriate association-repulsion balance to control supramolecular growth, and simultaneously shield the assemblies with enhanced stabilities.
View Article and Find Full Text PDFPAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding.
Pharmaceutics
October 2024
A.M. Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia.
Article Synopsis
- * The study introduces third generation PAMAM dendrimers with a thiacalixarene core in three different conformations, found to effectively bind and compact DNA while showing improved binding efficiency with generations.
- * The findings suggest that the structural design of these dendrimers can lower hemotoxicity and potentially simplify the development of new, cost-effective drug delivery systems in nanomedicine.
Smart β-cyclodextrin-dominated helical supramolecular dendritic assemblies improve the foliar affinity and biofilm disruption for treating alarming bacterial diseases.
Carbohydr Polym
January 2025
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals of Guizhou University, Guiyang 550025, China. Electronic address:
Recent outbreaks of alarming bacterial diseases have significantly impacted global agricultural productivity. Conventional bactericides exhibit certain limitations in efficiently impeding biofilm formation and annihilating biofilm-dispersed pathogens, and often expose to high off-target movement during foliar spraying. Here, we produce an innovative helical dendrimer-like supramolecular material (PhA28@β-CD) assembled by a bioactive small-molecule 2-chlorophenylisopropanolamine (PhA28) and β-cyclodextrin (β-CD) through host-guest recognition principle.
View Article and Find Full Text PDFUnwinding Spherical Helices Increases Entropy and Stability of Frank-Kasper and Body-Centered-Cubic Periodic Arrays To Facilitate Discrimination between Self-Organization Mechanisms.
J Am Chem Soc
November 2024
Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Spherical supramolecular dendrimers including helical, self-organize soft Frank-Kasper, other cubic such as body-centered cubic, and quasicrystal periodic and quasiperiodic arrays. When any of these periodic or quasiperiodic arrays forms immediately above a columnar phase, a supramolecular orientational memory effect was found to discriminate between mechanisms of self-organization of supramolecular spheres and generate unprecedented periodic arrays of helical columns which cannot be constructed by any other methodology. Here, we demonstrate that unwinding spherical helices, via their precursor nonhelical columns, increases the entropy and stability of their periodic and quasiperiodic spherical arrays and places the Frank-Kasper and other cubic phases immediately above the columnar phase.
View Article and Find Full Text PDFPolymer- and Lipid-Based Nanostructures Serving Wound Healing Applications: A Review.
Adv Healthc Mater
January 2025
Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, Gent, 9000, Belgium.
Management of hard-to-heal wounds often requires specialized care that surpasses the capabilities of conventional treatments. Even the most advanced commercial products lack the functionality to meet the needs of hard-to-heal wounds, especially those complicated by active infection, extreme bleeding, and chronic inflammation. The review explores how supramolecular nanovesicles and nanoparticles-such as dendrimers, micelles, polymersomes, and lipid-based nanocarriers-can be key to introducing advanced wound healing and monitoring properties to address the complex needs of hard-to-heal wounds.
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