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Unveiling Pediatric Neurosarcoidosis Mimicking Central Nervous System Tuberculosis: Diagnostic Challenges.
J Child Neurol
January 2025
Section of Pediatric Neurology, Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan.
Neurosarcoidosis is a rare chronic inflammatory disease affecting the nervous system. Owing to its varying manifestations that can mimic other central nervous system infectious or autoimmune diseases, and scarcity of literature, it proves to be a challenging diagnosis. We report two cases of possible neurosarcoidosis in the pediatric age group.
View Article and Find Full Text PDFA case report of refractory immune thrombocytopenia: Challenges in choice of therapies in resource limiting center.
Int J Surg Case Rep
January 2025
Assistant Professor of Surgery, College of Health Science, Deberetabor University, Debretabor, Ethiopia. Electronic address:
Introduction And Importance: Refractory immune thrombocytopenic purpura (ITP) is a rare but serious condition causing significant morbidity and mortality due to inadequate response to standard treatments, resulting in persistent thrombocytopenia and increased bleeding risk.
Case Presentation: An 18-year-old female patient, diagnosed with ITP two years prior following excessive vaginal bleeding and fatigue, was initially treated with oral prednisolone for two months and discharged in improved condition. Eighteen months after treatment cessation, she presented with recurrent excessive vaginal bleeding, intermittent bilateral nasal bleeding, skin rash, blurred vision, fatigue, tinnitus, vertigo, and intermittent headaches (one-month duration).
Rheumatoid arthritis and PLA2R-associated mebranous nephropathy. Cause or coincidence?
Clin Case Rep
December 2024
Nephrology Department, Regional University Hospital of Malaga University of Malaga, Biomedical Research Institute of Malaga (IBIMA)-Plataforma BIONAND, RICORS2040 (RD21/0005/0012) Malaga Spain.
Key Clinical Message: The coexistence of rheumatoid arthritis (RA) and PLA2R-associated membranous nephropathy (MN) is uncommon. It is difficult to demonstrate whether the mechanisms of renal pathology are triggered by RA, but it has been observed that the pro-inflammatory molecules present in RA increase the expression of PLA2R. Rituximab could be effective in both conditions.
View Article and Find Full Text PDFRituximab Administration to Treat Nephrotic Syndrome in Children: 2-Year Follow-Up.
Biomedicines
November 2024
Regional Children Hospital, 33027 Rivne, Ukraine.
Background: Steroid-sensitive nephrotic syndrome (SSNS) and steroid-resistant nephrotic syndrome (SRNS) significantly affect children's quality of life. There are frequent relapses in SSNS and progression in SRNS. IPNA guidelines suggest that monoclonal antibodies like rituximab (RTX) are promising treatments.
View Article and Find Full Text PDFCervical myelopathy caused by IgG4-related hypertrophic spinal pachymeningitis: Case report and a descriptive review of the literature.
Brain Spine
September 2024
Department of Neurosurgery, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
Article Synopsis
- IgG4-related disease is an immune disorder that can cause hypertrophic spinal pachymeningitis (HSP), leading to spinal cord and nerve root compression due to infiltration of IgG4-positive plasma cells in the meninges.* -
- A case study of a 45-year-old man with cervical myelopathy showed that surgical decompression and subsequent treatment with methylprednisolone and rituximab led to a full neurological recovery, highlighting effective management of this condition.* -
- An updated literature review covering 52 cases revealed that neurological impairment worsened in 58% of patients, with most lesions affecting the thoracic and cervical spine, indicating the complexities and challenges in diagnosing and treating IgG4-related H
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