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Disseminated Lichtheimia sp. Infection in a Buff-Headed Capuchin (Sapajus xanthosternos).
J Med Primatol
December 2024
Pathological Anatomy Sector (SAP), Federal Rural University of Rio de Janeiro (UFRuralRJ), Seropédica, Brazil.
A clinicopathologic picture caused by Lichtheimia sp. in a 33-year-old male Sapajus xanthosternos kept in a conservationist center is described. Acute apathy, vomiting, fever, and polydipsia were associated with pneumonia, enteritis, and gastritis presenting fibrinoid vasculitis containing hyphae.
View Article and Find Full Text PDFOrbital apex syndrome in a man with rhino-ocular cerebral mucormycosis: a case report.
J Med Case Rep
November 2024
Department of Emergency Medicine, Tawam Hospital, Al Ain, United Arab Emirates.
Background: Orbital apex syndrome is a symptom complex of visual loss and ophthalmoplegia resulting from a disease involving the orbital apex. It can be caused by inflammation, infection, and malignancies. Mucormycosis is an infection caused by filamentous saprophytes of the order Mucorales.
View Article and Find Full Text PDFSuccessful Management of Rhinofacial Conidiobolus coronatus Infection with Itraconazole Monotherapy.
Am J Trop Med Hyg
January 2025
Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, New Delhi, India.
There are no standard guidelines on the management of Conidiobolus infections, and many antifungals have been used, either alone or in combination. Relapses are common even after successful management. Although localized, they can result in severe facial disfigurement and may rarely cause disseminated entomophthoromycosis, which can have fatal complications.
View Article and Find Full Text PDFClinical characteristics and mortality of mucormycosis in hematological malignancies: a retrospective study in Eastern China.
Ann Clin Microbiol Antimicrob
August 2024
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China.
Article Synopsis
- Mucormycosis is a serious fungal infection that significantly impacts patients with blood cancers in eastern China, with this study focusing on its clinical features from 2018 to 2023.
- A total of 50 cases were analyzed, revealing that most patients were young adults (average age 40) predominantly suffering from acute myeloid leukemia, with pulmonary manifestations being the most common.
- The study found a high 90-day mortality rate of 76%, highlighting that early diagnosis and treatment with amphotericin B and surgery can improve survival rates, while certain factors like neutropenia worsen outcomes.
Risk Factors and Outcomes of Mucorales Infection in a Modern Cohort of Solid Organ Transplant, Hematopoietic Cell Transplant, and Chimeric Antigen Receptor T-cell Therapy Recipients.
Transplant Proc
September 2024
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
Article Synopsis
- Mucorales infections lead to high morbidity and mortality rates in immunocompromised patients, such as those receiving solid organ or hematopoietic cell transplants, despite advances in diagnosis and treatment.!* -
- A study analyzed 43 patients with Mucorales infections, finding that most developed the infection around 184 days post-transplant, with a 64% overall mortality rate; fatalities were mainly linked to Mucormycosis and common in disseminated disease.!* -
- The findings highlight a gap in effective prophylaxis and treatment strategies, indicating that improved data post-transplant can aid in managing Mucormycosis and emphasizing the need for further research on antifungal treatments.!
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