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Longer Total Interhospital Transfer Times for Rural Sepsis Patients Not Associated with Increased Mortality.
Prehosp Emerg Care
January 2025
Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Objectives: Sepsis is a time-sensitive condition, and many rural emergency department (ED) sepsis patients are transferred to tertiary hospitals. The objective of this study was to determine whether longer transport times during interhospital transfer are associated with higher sepsis mortality or increased hospital length-of-stay (LOS).
Methods: A cohort of rural adult (age ≥ 18y) sepsis patients transferred between hospitals were identified in the TELEmedicine as a Virtual Intervention for Sepsis Care in Emergency Departments (TELEVISED) parent study.
Identification of antigen-presenting cell-T cell interactions driving immune responses to food.
Science
December 2024
Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4 T cells and inducing their differentiation into regulatory (pTreg) or inflammatory (Th) subsets. We used a proximity labeling method (LIPSTIC) to identify APCs that presented dietary antigens under tolerizing and inflammatory conditions and understand cellular mechanisms by which tolerance to food is induced and can be disrupted by infection.
View Article and Find Full Text PDFThe Microbiome: From the Beginning to the End.
Mo Med
November 2024
Department of Otolaryngology, Saint Louis University School of Medicine, St. Louis, Missouri.
The human microbiota, a community of microorganisms in our bodies, is crucial for our health. This paper explores its development from birth through old age, highlighting some of the unique roles at key life stages-infancy, adulthood, and in the elderly years. Understanding the significant health impacts and consequences of changes in the microbiota offers insights for both the public and clinicians.
View Article and Find Full Text PDFCirculating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.
NPJ Parkinsons Dis
November 2024
Department of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA.
To identify circRNAs associated with Parkinson's disease (PD) we leveraged two of the largest publicly available studies with longitudinal clinical and blood transcriptomic data. We performed a cross-sectional study utilizing the last visit of each participant (N = 1848), and a longitudinal analysis that included 1166 participants with at least two time points. We identified 192 differentially expressed circRNAs, with effects that were sustained during disease, in mutation carriers, and diverse ancestry.
View Article and Find Full Text PDFEffects of intergenerational transmission of small intestinal bacteria cultured from stunted Bangladeshi children with enteropathy.
bioRxiv
November 2024
The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Article Synopsis
- Environmental enteric dysfunction (EED) is a condition impacting the small intestine, frequently seen in stunted children, characterized by damaged gut barrier and reduced nutrient absorption.
- A study with gnotobiotic mice showed that specific bacterial strains from stunted children can cause inflammation and immune changes similar to those found in EED, impacting gut and brain function.
- The research highlights a strain, Campylobacter concisus, as a potential contributor to gut issues, suggesting that targeting small intestinal microbiota could lead to new treatments for undernutrition across generations.
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