Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Relevance of platelet serotonergic mechanisms in pregnancy induced hypertension.
Life Sci
August 1994
Department of Pharmacology & Therapeutics, King George's Medical College, Lucknow, India.
Platelet functions are becoming the useful tool for delineating the etiology of pregnancy induced hypertension. Electronmicroscopic studies, efflux and content of 5-HT in platelets and platelet aggregation responses towards various aggregating agents have been measured in 25 normotensive pregnant subjects and 31 PIH subjects. Marked decrease changes have been noted in aggregation parameters with transformation from discoid to "spiny sphere" of platelets with long pseudopods along with prolonged time for spontaneous aggregation by platelets in PIH.
View Article and Find Full Text PDF5-Hydroxytryptamine dominates over thromboxane A2 in reducing collateral blood flow by activated platelets.
Am J Physiol
July 1993
Department of Cardiovascular Pharmacology, Janssen Research Foundation, Beerse, Belgium.
Intra-aortic infusion of collagen (100 micrograms/kg in 1 min) elicited an extensive platelet activation and transient but marked reductions of blood flow and increases of peripheral vascular resistance, both responses being more pronounced in collaterals than in normal arterial beds in feline hind legs. Blockade of 5-hydroxytryptamine (5-HT) subtype 2 (5-HT2) receptors for 5-HT (ketanserin or ritanserin, 0.63 mg/kg iv, -10 min) or amine depletion (reserpine, 0.
View Article and Find Full Text PDFGeneral pharmacological properties of the new vasodilator flosequinan.
Arzneimittelforschung
October 1992
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Japan.
Pharmacological effects of a new vasodilator, flosequinan (7-fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolone, BTS 49 465, CAS 76568-02-0) on the central nervous system, somatic nervous system, autonomic nervous system and smooth muscle, digestive system and miscellaneous organs were investigated. 1. The central nervous system: Flosequinan inhibited acetic acid-induced writhing at doses of more than 30 mg/kg p.
View Article and Find Full Text PDFGeneral pharmacological properties of the main metabolite of flosequinan.
Arzneimittelforschung
October 1992
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Japan.
The general pharmacological profile of 7-fluoro-1-methyl-3-(methylsulfonyl)- 4(1H)-quinolone BTS 53 554, CAS 76568-68-8), the main metabolite of a new vasodilator, flosequinan (BTS 49 465), was investigated. 1. The central nervous system: BTS 53 554 at the dose of 30 mg/kg i.
View Article and Find Full Text PDF[The neurohumoral mechanisms of adaptation to cryoinjury (frostbite)].
Vestn Ross Akad Med Nauk
April 1993
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!