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Insulin Resistance in Hypercalciuric Calcium Kidney Stone Patients.
Kidney Med
December 2024
Department of Medicine, University of Chicago, Chicago IL.
Rational & Objective: Diabetes and uric acid kidney stones are strongly associated. Patients with calcium kidney stones also have higher risk of developing diabetes compared with nonkidney stone patients yet this has not been further investigated. We aimed to characterize insulin resistance in calcium kidney stone patients.
View Article and Find Full Text PDFPediatric hypoparathyroidism: etiological and clinical evaluation in a tertiary center.
Endocrine
November 2024
Department of Pediatric Endocrinology, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye.
Purpose: This study aims to evaluate the etiology, clinical presentation, and management of pediatric hypoparathyroidism in a tertiary center.
Methods: A retrospective review was conducted on pediatric patients diagnosed with hypoparathyroidism at the Pediatric Endocrinology Clinic from March 2021 to June 2023. Data on demographic characteristics, presenting symptoms, laboratory findings, genetic analyses, and treatment outcomes were collected.
A narrative review of monogenic disorders causing nephrolithiasis and chronic kidney disease.
Nephrology (Carlton)
December 2024
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- - The incidence of genetic diseases linked to chronic kidney disease (CKD) has been on the rise, prompting a review of monogenic causes related to kidney stone disorders.
- - Identified monogenic conditions include primary hyperoxaluria, cystinuria, and Dent disease, all of which can lead to CKD and possibly progress to end-stage kidney disease (ESKD).
- - It's important to conduct genetic testing in children with kidney stones, as a significant number of these patients may develop CKD due to underlying genetic disorders.
miR-148b-5p regulates hypercalciuria and calcium-containing nephrolithiasis.
Cell Mol Life Sci
August 2024
Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510230, Guangdong, China.
Article Synopsis
- Calcium-containing kidney stones are the most common type and are often associated with idiopathic hypercalciuria, though their exact causes are still unclear.
- This study investigated the role of a specific microRNA, miR-148b-5p, found in urinary exosomes, which was linked to increased urinary calcium levels and stone formation in both rat models and human samples.
- The research indicates that miR-148b-5p lowers the expression of the calcitonin receptor (Calcr), playing a crucial role in regulating calcium excretion and kidney stone formation, and suggests that targeting this microRNA could lead to new treatments for this condition.
Kidney Stone Risk in Normocalcemic Hyperparathyroidism before and after Parathyroid Surgery.
Case Rep Endocrinol
July 2024
Division of Urology Alpert Medical School of Brown University, Providence, RI, USA.
Article Synopsis
- Higher risk of kidney stones in primary hyperparathyroidism is known, but the risk in normocalcemic primary hyperparathyroidism (NPHPT) is still unclear.
- A case study highlighted a patient with recurrent calcium kidney stones and severe idiopathic hypercalciuria despite having NPHPT.
- Surgical removal of the parathyroid adenoma did not decrease the patient's kidney stone risk or burden, prompting an examination of the relationship between the adenoma and stone formation in NPHPT.*
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