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applications of porcine ocular surface tissues: Advancing eye research and alternatives to animal studies.
Histol Histopathol
January 2025
Institute for Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.
The use of tissues of porcine origin has gained significant momentum in the scientific community due to their anatomical and physiological resemblance to human tissues. This review provides a comprehensive overview of the key biological features of porcine ocular structures, including the cornea, conjunctiva, and associated tissues, in comparison to their human counterparts. Additionally, this review outlined the ex vivo applications of these tissues in the study of different biological processes and the simulation of pathological conditions.
View Article and Find Full Text PDFStage 2 Registered Report: Propositional Thought Is Sufficient for Imaginal Extinction as Shown by Contrasting Participants With Aphantasia, Simulated Aphantasia, and Controls.
Psychophysiology
January 2025
Department of Psychology, University of Bonn, Bonn, Germany.
Imaginal exposure is a standard procedure of cognitive behavioral therapy for the treatment of anxiety and panic disorders. It is often used when in vivo exposure is not possible, too stressful for patients, or would be too expensive. The Bio-Informational Theory implies that imaginal exposure is effective because of the perceptual proximity of mental imagery to real events, whereas empirical findings suggest that propositional thought of fear stimuli (i.
View Article and Find Full Text PDFEffect of Low-Level Laser Acupuncture and Microcurrent Electrical Stimulation on Gag Reflex in Children During Dental Impression: A Randomized Controlled Clinical Trial.
Int J Paediatr Dent
January 2025
Faculty of Dentistry, Pediatric Dentistry and Dental Public Health Department, Alexandria University, Alexandria, Egypt.
Background: Dental impressions are crucial in pediatric dentistry, but exaggerated gagging can obstruct this process. Various methods have been proposed to manage the gag reflex (GR).
Aim: This study aimed to evaluate and compare the effectiveness of laser acupuncture and electroacupuncture in controlling children's GR.
Assessing time series correlation significance: A parametric approach with application to physiological signals.
Biomed Signal Process Control
August 2024
CNRS-University of Montpellier LIRMM, UMR5506, Interactive Digital Human, Montpellier, France.
Correlation coefficients play a pivotal role in quantifying linear relationships between random variables. Yet, their application to time series data is very challenging due to temporal dependencies. This paper introduces a novel approach to estimate the statistical significance of correlation coefficients in time series data, addressing the limitations of traditional methods based on the concept of effective degrees of freedom (or effective sample size, ESS).
View Article and Find Full Text PDFAlternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy.
Front Immunol
January 2025
The Lautenberg Center for Immunology and Cancer Research, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Alternative splicing (AS) is a mechanism that generates translational diversity within a genome. Equally important is the dynamic adaptability of the splicing machinery, which can give preference to one isoform over others encoded by a single gene. These isoform preferences change in response to the cell's state and function.
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