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Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival.
Science
January 2025
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, suggesting separate mechanisms are involved. Here, we found that the transcription factor Casz1 was crucial for early IHC fate consolidation and for OHC survival during mouse development. Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production.
View Article and Find Full Text PDFPrimary Leiomyosarcoma of the Thyroid.
Head Neck Pathol
January 2025
Department of medical oncology, Habib Bourguiba Hospital, University of Sfax, Sfax, 3029, Tunisia.
Leiomyosarcoma (LMS) is a malignant mesenchymal neoplasm showing smooth muscle differentiation. Primary LMS of the thyroid gland is quite rare, accounting for only 0.014% of cases.
View Article and Find Full Text PDFComplicated cases in foreign bodies of the ear, nose, and throat: a case series.
Colomb Med (Cali)
January 2025
Phayao Hospital, Otolaryngology unit, Phayao, Thailand Phayao Hospital Otolaryngology unit Phayao Thailand.
Background: Managing foreign bodies in otorhinolaryngology requires appropriate treatment based on case severity.
Objective: To analyze the clinical characteristics associated with complicated cases of foreign bodies.
Methods: This study categorized patients with diagnosed foreign bodies into complicated and uncomplicated cases.
Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease characterized by exocrine gland dysfunction. Mucormycosis is a rare yet life-threatening opportunistic fungal infection caused by species, with a high mortality rate. In patients undergoing long-term immunosuppressive therapy or corticosteroid use, especially when compounded by conditions such as diabetes or hyperlipidemia, Mucor can become pathogenic.
View Article and Find Full Text PDFExamining the Time to Diagnosis in Idiopathic Intracranial Hypertension Presentations in a Specialist Eye Emergency Department.
Cureus
December 2024
Emergency, Royal Victorian Eye and Ear Hospital, Melbourne, AUS.
Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by chronic headaches, cognitive difficulties, reduced quality of life, and rarely irreversible visual loss. Community diagnosis is often challenging due to unfamiliarity with current guidelines and a lack of clinical experience, leading to misdiagnosis and treatment delays, which can negatively impact visual recovery and quality of life. Our study examined the time to diagnosis and investigated the barriers to timely diagnosis in adults with newly diagnosed IIH.
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