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http://dx.doi.org/10.1073/pnas.48.7.1238 | DOI Listing |
Am J Physiol Gastrointest Liver Physiol
January 2025
Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Mucosal healing is the primary goal for Inflammatory Bowel Diseases (IBD) treatment. We previously showed the direct beneficial effects of rhamnogalacturonan (RGal) on intestinal epithelial barrier function. Here, we aimed to evaluate the effect of RGal in intestinal epithelial wound healing.
View Article and Find Full Text PDFAnn Hepatol
January 2025
Department of Hepato-Biliary-Pancreatic Surgery, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang City, 421001, Hunan, China. Electronic address:
Introduction And Objectives: Deregulation of mA methylation, the most prevailing RNA modification, participates in cancer pathogenesis. METTL16, an atypical methyltransferase, functions as a pro-tumorigenic factor in hepatocellular carcinoma (HCC). Here, we explored the action of METTL16 on HCC glycolysis and the associated mechanism.
View Article and Find Full Text PDFJ Biol Chem
November 2024
Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon, USA. Electronic address:
The mechanisms of action for the platinum compounds cisplatin and oxaliplatin have yet to be fully elucidated, despite the worldwide use of these drugs. Recent studies suggest that the two compounds may be working through different mechanisms, with cisplatin inducing cell death via the DNA damage response (DDR) and oxaliplatin utilizing a nucleolar stress-based cell death pathway. While cisplatin-induced DDR has been subject to much research, the mechanisms for oxaliplatin's influence on the nucleolus are not well understood.
View Article and Find Full Text PDFMol Biotechnol
September 2024
Laboratório de Parasitologia, Butantan Institute, São Paulo, Brazil.
Brazil has a very large biological variety, which is an almost inexhaustible source of substances of pharmacological and biotechnological interest. Several studies have demonstrated the presence of bioactive peptides in insect hemolymph and their potential use as therapeutic agents. However, few data are available regarding molecules extracted from insects with anti-apoptotic action.
View Article and Find Full Text PDFSci China Life Sci
January 2025
Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
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