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Brain Function and Marijuana: Are there Changes after Abstinence of Consumption? Preliminary Results.
Actas Esp Psiquiatr
June 2024
Departamento de Psiquiatría y Salud Mental Oriente, Facultad de Medicina, Universidad de Chile, 8330111 Santiago, Chile.
Background: The legalization of cannabis use and false claims about the plant Cannabis sativa to be considered a pharmaceutical product have been found to increase consumption, lower risk perception, and lead to more health problems, without reducing criminal activity. Brain function, typically assessed by neuropsychological tests, shows abnormalities with acute marijuana use, but inconsistent results have been published after abstinence, with a maximum follow-up of 28 days. Our previous research, using neuropsychological tests and brain perfusion single photon emission computed tomography (neuroSPECT), demonstrated consistent abnormalities in brain function among schoolchildren who consume marijuana compared to their non-consuming peers.
View Article and Find Full Text PDFDifferential effects of growth restriction and immaturity on predicted psychomotor development at 4 years of age in preterm infants.
AJOG Glob Rep
February 2024
Department of Paediatric Neurology, University of Giessen, Germany (Dr Neuhäuser).
Background: Fetal growth restriction and immaturity are associated with poor neurocognitive development and child psychopathology affecting educational success at school and beyond. However, the differential effects of either obstetrical risk factor on predicted psychomotor development have not yet been deciphered.
Objective: This study aimed to separately study the impact of growth restriction and that of immaturity on predicted psychomotor development at the preschool age of 4.
Comparative evaluation of intraoperative dexmedetomidine versus lidocaine for reducing postoperative cognitive decline in the elderly: a prospective randomized controlled trial.
Anaesthesiol Intensive Ther
February 2024
Department of Physiology, AIIMS, New Delhi, India India.
Introduction: Neuroinflammation, neuronal cytotoxicity, and apoptosis due to exposure to anaesthetic agents are often implicated in postoperative cognitive dysfunction (POCD). Lidocaine and dexmedetomidine have been shown to suppress the neuron-specific markers of inflammation, and we aimed to compare their neuroprotective efficacy in elderly patients.
Material And Methods: This prospective randomized control study compared the incidence of POCD in ASA I/II patients aged 60 to 80 years without any history of substance abuse or any disorder affecting cognition.
Cognitive disengagement syndrome in children with type 1 diabetes: important implications for clinical outcomes.
Acta Diabetol
January 2024
Division of Pediatric Endocrinology, Department of Child Health and Diseases, Faculty of Medicine, Sivas Cumhuriyet University, 58140, Sivas, Turkey.
Aims: Children with type 1 diabetes (T1D) are prone to a variety of psychiatric disorders, however, to date, no study has examined cognitive disengagement syndrome (CDS) in children with T1D. The present study aimed to evaluate the frequency of CDS symptoms in children with T1D and whether it is related to glycemic control.
Methods: This cross-sectional study included 74 children with T1D and 88 healthy (control) children, aged 8-14 years.
Comparative evaluation of isoflurane and desflurane for postoperative cognitive decline in elderly patients: A prospective observational pilot study.
J Perioper Pract
June 2024
Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, New Delhi, India.
Background: Approximately 16%-62% of patients undergoing non cardiac surgeries develop postoperative cognitive dysfunction. We compared the incidence of postoperative cognitive dysfunction in older adults aged 60-80 years who underwent open abdominal surgeries under general anaesthesia using isoflurane or desflurane and correlated it with the serum concentration of interleukin 1, interleukin 6, tumour necrosis factor alpha, amyloid β and S100 on postoperative day 3.
Method: Forty American Association of Anesthesiologists Physical Classification I or II patients were included after acquiring institutional ethics committee approval, registering in the Clinical Trials Registry - India, and informed written consent.
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