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Retrospective Analysis of the Correlation between Umbilical Blood Flow Index and Maternal and Fetal Outcomes in Pregnant Women with Gestational Diabetes.

Br J Hosp Med (Lond)

January 2025

Department of Obstetrics and Gynecology, The First Clinical Medical College of Three Gorges University, Yichang Central People's Hospital, Yichang, Hubei, China.

Gestational diabetes mellitus (GDM) is a common complication during pregnancy. This retrospective study investigates the correlation between umbilical blood flow index and maternal-fetal outcomes in pregnant women with GDM, aiming to contribute to evidence-based risk assessment and management strategy in this high-risk obstetric population. This retrospective study recruited 119 pregnant women with GDM who were admitted to the Yichang Central People's Hospital, between January 2022 and January 2024.

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Liver assistive devices in acute liver failure: Current use and future directions.

Best Pract Res Clin Gastroenterol

December 2024

Department of Critical Care Medicine, University of Alberta, Edmonton, Canada; Division of Gastroenterology (Liver Unit), University of Alberta, Edmonton, Canada. Electronic address:

Article Synopsis
  • * The only certain treatment for ALF is liver transplantation (LT); however, some patients, especially those with acetaminophen-related liver failure, might recover with medical support instead of needing LT.
  • * Extracorporeal liver support (ECLS) is a growing area of interest in treating ALF, aiming to help the liver by removing toxins and promoting regeneration, with two main types: artificial ECLS (like dialysis methods) and bioartificial ECLS (which uses live hepat
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Trends of extreme hyperbilirubinemia related infant mortality in select European countries (1990-2019).

Pediatr Res

November 2024

Division of Pediatrics and Neonatal Critical Care, "A. Béclère" Medical Center, Paris; Saclay University Hospital, APHP-Paris, Paris, France.

Article Synopsis
  • The study investigates trends in infant mortality rates linked to extreme neonatal hyperbilirubinemia (EHB) in six European countries from 1990 to 2019, revealing a significant decline in such mortality rates over the years.
  • Results showed a decrease in EHB-related infant mortality from 21.4 to 4.2 per million live births, with Germany showing the best improvement and Portugal the most significant decline rate.
  • The findings underscore the need for national surveillance and tailored guidelines to prevent bilirubin-induced neurological damage, highlighting substantial differences in mortality trends among the countries studied.
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Assessment of gnostic and stereognostic functions in patients with liver cirrhosis: A comparative study with healthy controls.

J Back Musculoskelet Rehabil

November 2024

2nd Department of Internal Medicine of the Slovak Medical University Faculty of Medicine, HEGITO (Division Hepatology, Gastroenterology and Liver Transplant), F. D. Roosevelt Teaching Hospital, Banská Bystrica, Slovakia.

Background: Individuals diagnosed with liver cirrhosis typically experience a variety of symptoms. Decompensation, a critical stage in the disease's progression, is characterized by the emergence of prominent clinical signs. These signs typically include ascites, bleeding tendencies, hepatic encephalopathy, and jaundice.

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Objective: Vascular hyporeactivity increases with the incidence of obstructive jaundice (OJ). Evidence suggests that OJ activates the farnesoid X receptor (FXR) as well as the large-conductance Ca-activated K (BK or MaxiK) channel. This study was designed to explore the role of the FXR in vascular hyporesponsiveness induced by cholestasis.

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