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Cigarette tar accelerates atherosclerosis progression via RIPK3-dependent necroptosis mediated by endoplasmic reticulum stress in vascular smooth muscle cells.
Cell Commun Signal
January 2024
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Background: Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression and the underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis and plaque vulnerability. The present study sought to investigate the mechanism of atherosclerosis progression through tar-induced VSMC necroptosis, a recently described form of necrosis.
View Article and Find Full Text PDFCigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway.
Free Radic Biol Med
May 2023
Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, PR China; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, 150001, PR China. Electronic address:
Despite the known promotional effects of cigarette smoking on progression of atherosclerosis (AS), tar as the most dominant toxic component in cigarette smoking has been little studied. Understanding the potential role and mechanisms of tar in AS may be a prerequisite for future reductions in cardiovascular morbidity and mortality. Male ApoE mice were fed with high-fat diet and injected intraperitoneally with cigarette tar (40 mg/kg/day) for 16 weeks.
View Article and Find Full Text PDFPhotocatalytic Degradation of Tobacco Tar Using CsPbBr3 Quantum Dots Modified Bi2WO6 Composite Photocatalyst.
Nanomaterials (Basel)
September 2021
School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China.
Polycyclic aromatic hydrocarbons (PAHs) in tobacco tar are regarded as a significant threat to human health. PAHs are formed due to the incomplete combustion of organics in tobacco and cigarette paper. Herein, for the first time, we extended the application of CsPbBr quantum dots (CsPbBr) to the photocatalytic degradation of tobacco tar, which was collected from used cigarette filters.
View Article and Find Full Text PDFImpact of chronic smoking on traumatic brain microvascular injury: An in vitro study.
J Cell Mol Med
August 2021
Department of Foundation Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
Traumatic brain injury (TBI) is a major reason of cerebrovascular and neurological damage. Premorbid conditions such as tobacco smoking (TS) can worsen post-TBI injuries by promoting vascular endothelial impairments. Indeed, TS-induced oxidative stress (OS) and inflammation can hamper the blood-brain barrier (BBB) endothelium.
View Article and Find Full Text PDFRapid Characterization of Drugs in Biological Fluid and Seized Material Using Thermal-Assisted Carbon Fiber Ionization Mass Spectrometry.
J Am Soc Mass Spectrom
April 2021
Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
Developing a rapid, simple, and sensitive method to analyze drugs is critical to forensic research study because of the widespread occurrence of the matrix effect. Herein, we develop a method using thermal-assisted carbon fiber ionization mass spectrometry that can be used to directly analyze drugs in biological fluid. The key feature of this technique is that the biological samples such as urine and blood can be achieved online as precipitated protein on the carbon fiber tip and thermally desorbed by the metal ceramics heater, which can reduce the matrix effects and improve the sensitivity.
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