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Crystallographic analysis of G-clamp-RNA complex assisted by large scale RNA-binding profile.
Chem Commun (Camb)
December 2024
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Miyagi 980-8577, Japan.
We present the X-ray crystal structure of a complex between a G-clamp and an internal loop motif of pre-mir-125a, selected from high affinity RNAs identified in a large-scale RNA-binding profile. This X-ray crystal structure reveals that the G-clamp interacts with three distinct guanine bases, forming robust bonds through hydrogen bonding and stacking interactions.
View Article and Find Full Text PDFGold-containing compound BDG-I inhibits the growth of A549 lung cancer cells through the deregulation of miRNA expression.
Saudi Pharm J
November 2018
Pharmaceutical Sciences Section, College of Pharmacy, Qatar University, Doha, Qatar.
Gold complex (diethyldithiocarbamato-gold(I)) (diphenylphosphino) methane (BDG-I) is cytotoxic toward different cancer cell lines. We compared the cytotoxic effect of BDG-I with that of cisplatin in the A549 lung cancer cell line. Additionally, we investigated the molecular mechanism underlying the toxic effect of BDG-I toward the A549 cell line and the identification of cancer-related miRNAs likely to be involved in killing the lung cancer cells.
View Article and Find Full Text PDFEnhancement of dissipated energy by large bending of an organic single crystal undergoing twinning deformation.
RSC Adv
June 2018
Department of Materials System Science, Graduate School of Nanobioscience, Yokohama City University 22-2 Seto, Kanazawa-ku Yokohama Kanagawa 236-0027 Japan
We demonstrate exceptional twinning deformation in a molecular crystal upon application of mechanical stress. Crystal integrity is preserved and the deformation is associated with a large bending angle (65.44°).
View Article and Find Full Text PDFStructural and microstructural aspects of asbestos-cement waste vitrification.
Spectrochim Acta A Mol Biomol Spectrosc
April 2018
Czestochowa University of Technology, Institute of Materials Engineering, 19 Armii Krajowej St., 42-200 Czestochowa, Poland.
The main goal of the work was to evaluate the vitrification process of asbestos-cement waste (ACW). A mixture of 50 wt% ACW and 50 wt% glass cullet was melted in an electric furnace at 1400 °C for 90 min and then cast into a steel mold. The vitrified product was subjected to annealing.
View Article and Find Full Text PDFXRD- and infrared-probed anisotropic thermal expansion properties of an organic semiconducting single crystal.
Phys Chem Chem Phys
January 2018
Dept. of Engineering and Architecture, University of Trieste, V. Valerio 10, 34100 Trieste, Italy.
The anisotropic thermal expansion properties of an organic semiconducting single crystal constituted by 4-hydroxycyanobenzene (4HCB) have been probed by XRD in the range 120-300 K. The anisotropic thermal expansion coefficients for the three crystallographic axes and for the crystal volume have been determined. A careful analysis of the crystal structure revealed that the two different H-bonds stemming from the two independent, differently oriented 4HCB molecules composing the unit cell have different rearrangement patterns upon temperature variations, in terms of both bond length and bond angle.
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