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Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long-Term Cardiovascular Mortality.
J Am Heart Assoc
January 2025
Research Institute of Internal Medicine, Oslo University Hospital Oslo Norway.
Background: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.
Methods And Results: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H in patients with advanced carotid atherosclerosis in a (n=324) and in a (n=206) cohort in relation to adverse outcome (mean follow-up 7.
Recurrent meningococcal infections as a sign of inborn error immunity.
Epidemiol Mikrobiol Imunol
December 2024
Invasive meningococcal diseases (IMD) caused by Neisseria meningitidis are generally rare. They affect mostly selected age categories and risk groups of patients (in terms of age, comorbidities, or applied therapy), and the immune system and its defects may play an important modifying role. Meningococcal infections could be the first and only clinical sign of unrecognised immunodeficiency.
View Article and Find Full Text PDFPlasma-based proteomic and metabolomic characterization of lung and lymph node metastases in cervical cancer patients.
J Pharm Biomed Anal
January 2025
Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China; Key Laboratory for Molecular Medicine and Chinese Medicine Preparations, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. Electronic address:
Article Synopsis
- - Metastasis is a major concern in cervical cancer (CC), particularly affecting lymph nodes and lungs, leading to poor patient outcomes and limited predictive tools for determining metastasis risk.
- - The study analyzed plasma samples from CC patients with and without metastasis using advanced proteomics and metabolomics techniques, revealing common inflammatory processes and distinct metabolic changes between lung and lymph node metastasis groups.
- - Researchers identified two promising biomarker panels for predicting lung and lymph node metastasis, demonstrating strong diagnostic potential with high accuracy in both training and testing sets.
Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration.
MAbs
October 2024
Research and Product Development, Alexion, AstraZeneca Rare Disease, New Haven, CT, USA.
Article Synopsis
- Tarperprumig (ALXN1820) is a bispecific antibody designed to treat conditions caused by dysregulated activity in the complement alternative pathway, usable via small volume injections either under the skin or intravenously.
- It consists of two variable domains that target properdin and human serum albumin, showing a high binding affinity and forming a stable complex.
- The antibody effectively inhibits key processes related to complement pathway activation and is currently undergoing clinical development for relevant disorders.
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