AI Article Synopsis
- The study investigated how different bioresorbable carriers, combined with demineralized bone matrix, affect tissue response and bone formation in the abdominal muscles of rats.
- Fibrin-collagen paste and fibrin sealant were found to hinder bone formation and led to chronic inflammation, with remnants of the paste still detectable after four weeks.
- In contrast, polyorthoester with gentamicin was nearly fully absorbed by the body, caused minimal tissue reaction, and did not negatively impact bone formation.
Article Abstract
Host tissue response and heterotopic osteoinduction by composites of demineralized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealant inhibited bone induction and produced a chronic inflammation; part of the fibrin-collagen paste was still present at 4 weeks. Polyorthoester with gentamicin was almost completely absorbed, induced minimal tissue reaction, and did not inhibit osteoinduction.
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| http://dx.doi.org/10.1016/0278-2391(92)90231-n | DOI Listing |
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