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A single RBM20 missense variant is a potential contributor to dilated cardiomyopathy and/or isolated left ventricular dilatation in the Emilia Romagna region of Italy.
Int J Cardiol
January 2025
Medical Genetics Unit, Romagna Agency of Health, Italy.
Background: non-syndromic dilated cardiomyopathy (DCM) is found to correlate with a genetic cause in 30-40 % of cases. The identification of a causative gene variant can guide treatment options and cascade testing of at-risk family members. Cardiomyopathy multigene panels are routinely used to identify the genetic cause, but often detect variants of uncertain significance (VUS).
View Article and Find Full Text PDFContact Lenses in Therapeutic Care: A Comprehensive Review of Past Innovations, Present Applications, and Future Directions.
Adv Exp Med Biol
January 2025
Department of Optometry, University of Benin, Benin City, Nigeria.
Contact lenses have become integral tools in the realm of ocular therapeutics, extending beyond their primary function of refractive correction to encompass a diverse array of therapeutic applications. This review explores the evolving role of contact lenses in managing various ocular conditions, highlighting their efficacy in enhancing patient outcomes. Initially developed to correct refractive errors, contact lenses now serve as effective vehicles for delivering medications directly to the ocular surface, offering targeted treatment for conditions such as dry eye syndrome and corneal ulcers.
View Article and Find Full Text PDFAdvanced UltraTech approach for distinguishing granulomatous from non-granulomatous corneal endothelial exudates in autoimmune rheumatic anterior uveitis.
J Biol Methods
November 2024
Department of Medicine and Surgery, University of Enna Kore, Enna 94100, Italy.
Background: Anterior uveitis is a common manifestation in individuals with rheumatic conditions such as spondylarthritis, Behçet's syndrome, juvenile idiopathic arthritis, and sarcoidosis. Clinical differentiation between granulomatous and non-granulomatous corneal endothelial exudates is crucial to subsequent diagnosis and treatment. Anterior segment optical coherence tomography (AS-OCT) can ensure an accurate differential diagnosis and appropriate follow-up after local and systemic therapy.
View Article and Find Full Text PDFRespiratory Virus-Specific and Time-Dependent Interference of Adenovirus Type 2, SARS-CoV-2 and Influenza Virus H1N1pdm09 During Viral Dual Co-Infection and Superinfection In Vitro.
Viruses
December 2024
Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 48, I-50134 Florence, Italy.
Background: Understanding the interference patterns of respiratory viruses could be important for shedding light on potential strategies to combat these human infectious agents.
Objective: To investigate the possible interactions between adenovirus type 2 (AdV2), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A/H1N1 pandemic (H1N1pdm09) using the A549 cell line.
Methods: Single infections, co-infections, and superinfections (at 3 and 24 h after the first virus infection) were performed by varying the multiplicity of infection (MOI).
Umbilical Cord Blood-Derived Products in Autoimmune Systemic Syndromes with Severe Dryness: A Pilot Study.
Medicina (Kaunas)
October 2024
Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Article Synopsis
- Human umbilical cord blood serum (HUCBS) shows promise as an effective treatment for severe ocular surface disorders (OSDs) by speeding up healing and reducing inflammation, benefiting patients who haven't found relief through standard therapies.
- A study of 49 patients with various severe OSDs was conducted at San Marco Hospital in Italy, categorizing patients based on causes like rheumatologic diseases and graft-versus-host disease.
- Results indicated significant improvement in multiple assessments, including patient-reported outcomes and clinical evaluations, demonstrating the potential of HUCBS in treating resistant cases of OSDs.
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