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The C-MAC video laryngoscope helps presbyopic anesthetists to overcome difficulty in neonatal and infantile intubation: a randomized controlled trial.
BMC Anesthesiol
January 2025
Department of Anesthesia, ICU & Pain, Faculty of Medicine (Boys), Al-Azhar University, Cairo, Egypt.
Background: Endotracheal intubation (ETI) is a life-saving procedure that must be accurately carried on to guard against complications. Presbyopia leads to difficulty in viewing close objects and may obstacle proper intubation even with the best hands.
Purpose: This study supposed that the use of video-laryngoscope (VL) may provide better intubation conditions for presbyopic anesthetists and targets to evaluate the neonates and infants' intubation success rates (ISR) by anesthetists aged ≥ 45 years using the C-MAC VL compared to the standard laryngoscope (SL).
Early Results of an Infant Model of Orthotopic Cardiac Xenotransplantation.
J Heart Lung Transplant
January 2025
Division of Cardiac Surgery, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA. Electronic address:
Background: Genetically engineered porcine hearts may have an application for infants in need of a bridge to cardiac allotransplantation. The current animal model that resulted in 2 human applications has been validated in adult non-human primates only. We sought to create an infant animal model of life sustaining cardiac xenotransplantation to understand limitations specific to this age group.
View Article and Find Full Text PDFPeripapillary Retinal Nerve Fiber Layer (pRNFL) Thickness - A Novel Biomarker of Neurodegeneration in Late-Infantile CLN2 Disease.
Eye Brain
November 2024
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Article Synopsis
- This study aimed to examine the degeneration of peripapillary retinal nerve fiber layer (pRNFL) in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease and to assess pRNFL thickness using optical coherence tomography (OCT) as a potential indicator of disease progression.
- The research involved 20 diagnosed patients who received regular enzyme replacement therapy, with OCT imaging conducted under anesthesia; results showed a significantly lower mean pRNFL thickness compared to healthy children, indicating degeneration.
- Results highlighted that pRNFL thickness correlated strongly with age and clinical scales used to evaluate motor and language abilities, suggesting that pRNFL can serve as a useful biomarker for monitoring the progression of CL
Managing the neuroinflammatory pain of endometriosis in light of chronic pelvic pain.
Expert Opin Pharmacother
December 2024
Department of Maternal and Infantile Health and Urology, Sapienza University of Rome, Rome, Italy.
Introduction: Endometriosis affects 5% to 10% of reproductive age women and may be associated with severely painful and debilitating symptoms as well as infertility. Endometriosis involves hormonal fluctuations, angiogenesis, neurogenesis, vascular changes and neuroinflammatory processes. The neuroinflammatory component of endometriosis makes it a systemic disorder, similar to other chronic epithelial inflammatory conditions.
View Article and Find Full Text PDFStrategic Integration: A Cross-Disciplinary Review of the fNIRS-EEG Dual-Modality Imaging System for Delivering Multimodal Neuroimaging to Applications.
Brain Sci
October 2024
Research Center of Optical Instrument and System, Ministry of Education and Shanghai Key Lab of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China.
: Recent years have seen a surge of interest in dual-modality imaging systems that integrate functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) to probe brain function. This review aims to explore the advancements and clinical applications of this technology, emphasizing the synergistic integration of fNIRS and EEG. The review begins with a detailed examination of the fundamental principles and distinctive features of fNIRS and EEG techniques.
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