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The Nasal Innate Immune Proteome After Saline Irrigation: A Pilot Study in Healthy Individuals.
Am J Rhinol Allergy
July 2023
College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Background: Previous research has shown diminished nasal immune function following nasal saline irrigation (NSI), returning to baseline at 6 hours. The aim of this study was to examine the immune nasal proteome before and after 14 days of nasal irrigation.
Methods: Seventeen healthy volunteers received either isotonic (IsoSal) or low salt (LowNa) NSI.
Mucus composition abnormalities in sinonasal mucosa of chronic rhinosinusitis with and without nasal polyps.
Inflammation
October 2021
Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Mucus secretion and its composition are vital in the maintenance of airway health, among which hypoxia-inducible factors (HIFs) are thought to be involved in the regulation of mucin synthesis and regulation. Nasal mucus composition difference between healthy individuals and chronic rhinosinusitis (CRS) patients may contribute to the pathology of chronic nasal diseases, but so far, their role has yet to be completely understood. Nasal biopsy specimens were obtained from 24 healthy subjects and 99 patients with CRS without (CRSsNP, n=36) or with (CRSwNP, n=63) nasal polyps.
View Article and Find Full Text PDFDiffuse maculopapular exanthema and a positive lymphocyte transformation test reaction in response to clarithromycin.
Oxf Med Case Reports
September 2018
Division of Internal Medicine, Department of Internal Medicine, Chitose City Hospital, Hokkaido, Japan.
Macrolides are one of the most widely used antibiotics, but the mechanisms underlying macrolide allergy have not been clearly elucidated. Diffuse maculopapular exanthema caused by clarithromycin is extremely rare, of which clinical images have not been reported. Here, we report a case of a 55-year-old Japanese female who was treated with oral clarithromycin and lysozyme hydrochloride due to odontogenic maxillary sinusitis.
View Article and Find Full Text PDFPlant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa.
PLoS One
October 2017
Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.
Flavones are a class of natural plant secondary metabolites that have anti-inflammatory and anti-bacterial effects. Some flavones also activate the T2R14 bitter taste receptor, which is expressed in motile cilia of the sinonasal epithelium and activates innate immune nitric oxide (NO) production. Flavones may thus be potential therapeutics for respiratory infections.
View Article and Find Full Text PDFDifferential protein expression in the secretory fluids of maxillary sinusitis and maxillary retention cyst.
Eur Arch Otorhinolaryngol
January 2017
Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, 123 Chibyun-dong, Gangneung, 210-702, Korea.
Both maxillary sinusitis (MS) and maxillary retention cyst (MRC) involve the maxillary sinus and show similar clinical features. Clinically, differentiating between MS and MRC is sometimes difficult in asymptomatic patients, despite their quite different pathogenic behaviors. To identify differential protein expressions in the secretory fluids of MS and MRC, 25 cases of asymptomatic MS and 15 cases of asymptomatic MRC were examined pathologically in this study.
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