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Local anaesthetic to reduce injection pain in patients who are prescribed intramuscular benzathine penicillin G: a systematic review and meta-analysis.
EClinicalMedicine
October 2024
Institute of Health Informatics Research, University College London, London, UK.
Article Synopsis
- Prolonged intramuscular injections of benzathine penicillin G (BPG) are essential for preventing group A streptococcal infections and reducing the risk of rheumatic fever and heart disease, but the pain from these injections may reduce patient compliance.
- * This systematic review and meta-analysis aimed to evaluate the effectiveness of local anaesthetics in reducing pain associated with BPG injections by analyzing randomised controlled trials comparing BPG alone to BPG with anaesthetics.
- * Out of 3958 records, eight trials with 489 patients were included, revealing that while patients reported high levels of immediate pain, some still experienced low-intensity pain 24 hours later.
Prolongation of the Time Window From Traumatic Limb Amputation to Replantation From 6 to 33 Hours Using Ex Vivo Limb Perfusion.
Mil Med
August 2024
Department for BioMedical Research, DBMR, University of Bern, Bern 3008, Switzerland.
Introduction: Continuous extracorporeal perfusion (ECP), or machine perfusion, holds promise for prolonged skeletal muscle preservation in limb ischemia-reperfusion injury. This study aimed to extend the amputation-to-replantation time window from currently 6 hours to 33 hours using a 24-hour ECP approach.
Materials And Methods: Six large white pigs underwent surgical forelimb amputation under general anesthesia.
Efficacy of HER2-Targeted Intraperitoneal Ac α-Pretargeted Radioimmunotherapy for Small-Volume Ovarian Peritoneal Carcinomatosis.
J Nucl Med
September 2023
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Epithelial ovarian cancer (EOC) is often asymptomatic and presents clinically in an advanced stage as widespread peritoneal microscopic disease that is generally considered to be surgically incurable. Targeted α-therapy with the α-particle-emitting radionuclide Ac (half-life, 9.92 d) is a high-linear-energy-transfer treatment approach effective for small-volume disease and even single cells.
View Article and Find Full Text PDFBenzonatate as a local anesthetic.
PLoS One
April 2023
Laboratory for Biomaterials and Drug Delivery, Boston Children's Hospital, Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts, United States of America.
Introduction: Benzonatate is an FDA-approved antitussive agent that resembles tetracaine, procaine, and cocaine in its chemical structure. Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will act as a local anesthetic to yield peripheral nerve blockade.
Methods: Benzonatate was injected at the sciatic nerve of Sprague-Dawley rats.
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