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From the ports to the hinterland. Plague, bacteriology, and politics in Argentina (1899-1940).
Hist Philos Life Sci
November 2024
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET-Argentina)/CCTS-UMAI-UNLa, Buenos Aires, Argentina.
Article Synopsis
- In 1899, Paraguay and Buenos Aires experienced the onset of the third plague pandemic, which gradually advanced into the Argentinian interior over the early 20th century.
- Argentine bacteriologists emerged as key figures in recognizing and managing the plague, impacting both scientific development and public health strategies in Argentina and South America.
- The study delineates two phases of plague as a scientific and political issue: initially focused on urban port areas and later revealing its rural aspects, demonstrating Argentina's role in the global discourse on bacteriology.
Senotherapeutic Drugs: A New Avenue for Skincare?
Plast Reconstr Surg
December 2021
From SENISCA; and University of Exeter Medical School, University of Exeter.
Skin aging is an outward manifestation of other cellular and molecular aging processes occurring elsewhere in the body. These processes are known collectively as the "hallmarks" of aging, which are a series of basic health maintenance mechanisms that fail over time. Cellular senescence is one of the most studied of the hallmarks of aging; senescent cells accumulate over time and are major drives of the aging process.
View Article and Find Full Text PDFMatched related hematopoietic cell transplant for sickle cell disease with alemtuzumab: the Texas Children's Hospital experience.
Bone Marrow Transplant
November 2021
Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
Article Synopsis
- Serotherapeutic agents like anti-thymocyte globulin and alemtuzumab are used to improve outcomes in hematopoietic stem cell transplants (HCT) by aiding engraftment and reducing the risk of graft-versus-host disease (GVHD), particularly in sickle cell disease patients.
- A study of 38 patients at Texas Children's Hospital showed high rates of engraftment and low instances of acute and chronic GVHD after using alemtuzumab during myeloablative conditioning, with the median follow-up being 4.8 years.
- Although infections like cytomegalovirus were common after transplant, they did not lead to death, indicating that alemtuzumab may be a promising option for H
Diphtheria toxin (DT) is a unique bacterial protein, which selectively kills certain cell populations due to strict functional specialization of domains that allows using this toxin in protein engineering for constructing recombinant derivatives with defined properties. The article covers structural and functional features of DT molecule, both fundamental and practical aspects of recombinant DT derivatives' applications in different fields. In particular, applications of recombinant DT derivatives as unique instruments for fundamental research of cell receptors' functions, mechanism of DT action and participation of different cell populations in biological processes are presented.
View Article and Find Full Text PDFImmunological aspects of scorpion toxins: current status and perspectives.
Inflamm Allergy Drug Targets
October 2011
Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunisia.
Significant progress has been made in immunological studies of scorpion toxins and several formats of antibodies directed against scorpion toxins have been reported. Some of these are commonly used in a specific treatment against envenoming; others are primarily used for immuno-biochemical characterizations. The preparation protocol of the antibody or its fragments can be substantially different from one laboratory to another, which complicates a direct comparison of the potency of the antivenom.
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