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Cyclosporine-induced gingival overgrowth-Review.

Dermatol Ther

December 2022

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, Olsztyn, Poland.

Article Synopsis
  • - Drug-induced gingival overgrowth (DIGO) is an adverse effect linked to medications like phenytoin, calcium channel blockers, and cyclosporine A, leading to severe gum problems and potential tooth loss.
  • - The condition is associated with factors such as poor oral hygiene, and it mostly affects young males, especially children and adolescents.
  • - Treatment options include removing tartar and irritants, with gingivectomy being a common surgical procedure for addressing DIGO symptoms.
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Evaluation of Electrosurgery and Diode Laser in Gingival Depigmentation.

J Pharm Bioallied Sci

July 2022

Senior Lecturer, Department of Oral Medicine And Radiology, Pdm Dental College & Research Institute, Bahadurgarh, Jhajjar, Haryana, India.

Introduction: Gingival depigmentation is a surgical procedure done to eliminate or reduce gingival hyperpigmentation. Various techniques are employed such as scalpel de-epithelization, gingivectomy, electrosurgery, use of chemical agents, cryosurgery, and lasers. The present study was conducted to assess the efficacy of laser and electrosurgical procedure in reducing gingival pigmentation in terms of pain, wound healing, and recurrence of melanin pigmentation.

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Gingival overgrowth is a common side effect of calcium channel blockers used in the treatment of cardiovascular diseases. While controversial, management includes discontinuing the calcium channel blocker. We report the case of a 66-year-old Japanese man with hypertension and type 2 diabetes mellitus who was diagnosed with severe periodontitis covering almost all the teeth.

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Introduction: Gingival enlargement (GE) due to anti-epileptic drugs (AEDs) shows a high prevalence rate. However, lamotrigine, a newer AED, has not shown to induce GE. The present case report describes a rare case of GE in a patient with epilepsy under lamotrigine therapy for the past 3 years.

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Background: Gingival enlargement due to calcium channel blockers is a common complaint reported by patients. It can be localized or generalized and can range from mild to severe, affecting patients appearance and function. Nifedipine induced gingival enlargement is noticed only in 10 % of patients and very few cases of Nifedipine induced gingival enlargement in an edentulous patient have been documented in the literature.

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