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Feasibility and safety of Taipei Veterans General Hospital Heavy Ion Therapy Center: The first carbon-ion irradiation facility in Taiwan.
J Chin Med Assoc
January 2025
Department of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Background: Unlike conventional photon radiotherapy, particle therapy has the advantage of dose distribution. Carbon-ion radiotherapy is also advantageous in terms of biological effectiveness and other radiobiological aspects. These benefits lead to a higher response probability for previously known radioresistant tumor types.
View Article and Find Full Text PDFThe Space Radiobiological Exposure Facility on the China Space Station.
Astrobiology
January 2025
Institute of Environmental System Biology, Dalian Maritime University, Dalian, China.
The Space Radiobiological Exposure Facility (SREF) is a general experimental facility at the China Space Station for scientific research in the fields of space radiation protection, space radiation biology, biotechnology, and the origin of life. The facility provides an environment with controllable temperatures for experiments with organic molecules and model organisms such as small animals, plant seeds, and microorganisms. The cultivation of small animals can be achieved in the facility with the use of microfluidic chips and images and videos of such experiments can be captured by microscopy.
View Article and Find Full Text PDFAdded Value of Biological Effective Dose in Dosiomics-Based Modelling of Late Rectal Bleeding in Prostate Cancer.
Cancers (Basel)
December 2024
Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Background/objectives: Extracting spatial features (texture analysis) from dose distributions (dosiomics) for outcome prediction is a rapidly evolving field in radiotherapy. To account for fraction size differences, the biological effective dose (BED) is often calculated. We evaluated the impact and added value of the BED in the dosiomics prediction modelling of grade ≥ 2 late rectal bleeding (LRB) probability within 5 years after treatment in three parts.
View Article and Find Full Text PDFInfluence of stromal neural crest progenitor cells on neuroblastoma radioresistance.
Int J Radiat Biol
January 2025
Departamento de Biología Celular, Universidad de Sevilla, Seville, Spain.
Purpose: A substantial proportion of children with high risk Neuroblastoma die within the first 5 years post-diagnosis despite the complex treatment applied. In the recent years, tumor environment has been revealed as key factor for cancer treatment efficacy. In this sense, non-tumorigenic Neural Crest progenitor cells from high risk patients, have been described as part of Neuroblastoma stroma, promoting tumor growth and contributing to mesenchyme formation.
View Article and Find Full Text PDFExamination of immunohistochemical of the effects of flattened and unflattened radiotherapy beams in nude mice breast cancer xenografts.
Int J Radiat Biol
January 2025
Department of Neurosurgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Purpose: The aim of this study was to investigate the radiobiological effects underlying the inhibition of breast cancer (BCa) following radiotherapy in nude mice models, and to evaluate the impact of changes in immunohistochemical parameters induced by FF and FFF beams.
Materials And Methods: The study included thirty-six adult nude mouse models, which were randomly assigned to five groups: control (G1), breast cancer (BCa) (G2), FF-400 MU/min (G3), FFF-1100 MU/min (G4), and FFF-1800 MU/min (G5). The control group received neither radiation nor treatment, while the BCa group had a cancer model without radiation.
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