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BMJ Neurol Open
August 2024
Neurology, Duke University, Durham, North Carolina, USA.
Introduction: Epilepsy surgery is the only curative treatment for patients with drug-resistant focal epilepsy. Stereoelectroencephalography (SEEG) is the gold standard to delineate the seizure-onset zone (SOZ). However, up to 40% of patients are subsequently not operated as no focal non-eloquent SOZ can be identified.
View Article and Find Full Text PDFJ Thromb Haemost
July 2024
School of Medicine, Keele University, Newcastle-under-Lyme, United Kingdom. Electronic address:
J Clin Med
November 2023
Center for Treatment Comparison and Integrative Analysis, Tufts University School of Medicine, Boston, MA 02116, USA.
Background: Intra-articular hyaluronic acid (IAHA) products are often used in the treatment of adults with mild-to-moderate knee osteoarthritis (KOA). The International Symposium on Intra-Articular Treatment (ISIAT) convened a multidisciplinary technical expert panel to define characteristics for an innovative IAHA product that should answer unmet needs in the clinical management of adults with mild-to-moderate KOA.
Methods: An initial set of evidence-based statements was developed based on data extracted from articles identified through a comprehensive literature search.
Ther Adv Musculoskelet Dis
February 2023
Department of Orthopaedics and Traumatology, 'Policlinico Tor Vergata' Foundation, Rome, Italy.
Background: Early stage of osteoarthritis (OA) is characterized by joint stiffness and pain as well as by subclinical structural changes that may affect cartilage, synovium, and bone. At the moment, the lack of a validated definition of early osteoarthritis (EOA) does not allow to make an early diagnosis and adopt a therapeutic strategy to slow disease progression. Also, no questionnaires are available to evaluate the early stage, and therefore this remains an unmet need.
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