Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Antiedematogenic and Anti-Inflammatory Effects of the Essential Oil from the Fruits of Piper tuberculatum Jacq. (Piperaceae) in Animal Models.
Chem Biodivers
November 2024
1-Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry, Regional University of Cariri, 1161 Colonel Antônio Luis Street, Pimenta, Postal Code, 63105-000, Crato, Ceará, Brazil.
Piper tuberculatum, traditionally known in Brazil as 'pimenta-d'arda,' 'pimenta-longa,' or 'pimenta de macaco,' has been used in Brazilian folk medicine to treat inflammatory symptoms. Considering this species' significant essential oil content, the present study aimed to evaluate the anti-edematogenic and anti-inflammatory effects of the crucial oil Piper tuberculatum (EOPT) in vivo. To this end, Swiss mice (Mus musculus) of both sexes were treated orally with the EOPT at 50, 100, and 250 mg/Kg.
View Article and Find Full Text PDF-Derived Extracellular Vesicles Modulate Macrophage Polarization and Gut Homeostasis for Alleviating Ulcerative Colitis.
J Agric Food Chem
July 2024
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212003, China.
Extracellular vesicles released by probiotics have been demonstrated to effectively alleviate intestinal inflammation, yet the precise underlying mechanisms remain unclear. In this research, for the first time, UJS001 (LP-UJS) was isolated from fermented sauerkraut in Zhenjiang, China. Thereafter, the therapeutic effect of LP-UJS-derived extracellular vesicles (LP-UJS-EVs) on dextran sulfate sodium-induced ulcerative colitis (UC) in mice was analyzed to elucidate the immune mechanisms.
View Article and Find Full Text PDFThe histamine H receptor antagonist 1-[(5-chloro-2,3-dihydro-1-benzofuran-2-yl)methyl]-4-methyl-piperazine(LINS01007) prevents the development of DSS-induced colitis in mice.
Int Immunopharmacol
May 2024
Department of Pharmaceutical Sciences, Universidade Federal de São Paulo-campus Diadema, Diadema, SP, Brazil. Electronic address:
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with growing incidence worldwide. Our group reported the compound 5-choro-1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine (LINS01007) as HR antagonist (pK 6.2) and therefore the effects and pharmacological efficacy on a DSS-induced mice model of UC were assessed in this work.
View Article and Find Full Text PDFAntiedematogenic and Analgesic Activities of Abietic Acid in Mice.
Chem Biodivers
December 2023
Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri (URCA), Crato, CE-63105-000, Brazil.
Exacerbated inflammatory responses to harmful stimuli can lead to significant pain, edema, and other complications that require pharmacological intervention. Abietic acid (AA) is a diterpene found as a significant constituent in pine species, and evidence has identified its biological potential. The present study aimed to evaluate abietic acid's antiedematogenic and anti-inflammatory activity in mice.
View Article and Find Full Text PDFMulti-omics analysis reveals the interaction of gut microbiome and host microRNAs in ulcerative colitis.
Ann Med
October 2023
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Background: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract that co-occurs with gut microbiota dysbiosis; however, its etiology remains unclear. MicroRNA (miRNA)-microbiome interactions play an essential role in host health and disease.
Methods: To investigate the gut microbiome and host miRNA profiles in colitis, we used a Dextran Sulfate Sodium (DSS)-induced ulcerative colitis (UC) model.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!