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Eco-friendly stability-indicating HPTLC micro-determination of the first FDA approved SARS-CoV-2 antiviral prodrug Remdesivir: Study of degradation kinetics and structural elucidation of the degradants using HPTLC-MS.
Sustain Chem Pharm
October 2022
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, 21521, Alexandria, Egypt.
The worldwide spread coronavirus (covid-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) represents a global health crisis. The world was forced to face a great challenge to control and overcome this health disaster through various containment measures including efficient vaccination side by side with effective medication. Remdesivir (RMD) is the first FDA approved antiviral agent for treatment of covid-19 pandemic and hence regarded as the first-in-class medication of this highly contagious respiratory disease.
View Article and Find Full Text PDFScreening and development of enzymes for determination and transformation of amino acids.
Biosci Biotechnol Biochem
August 2019
a Biotechnology Research Center and Department of Biotechnology , Toyama Prefectural University, Imizu , Toyama , Japan.
The high stereo- and substrate specificities of enzymes have been utilized for micro-determination of amino acids. Here, I review the discovery of l-Phe dehydrogenase and its practical use in the diagnosis of phenylketonuria in more than 5,400,000 neonates over two decades in Japan. Screening and uses of other selective enzymes for micro-determination of amino acids have also been discussed.
View Article and Find Full Text PDFMicrodetermination of Sialic Acids in Blood Samples by Hydrophilic Interaction Chromatography Coupled to Post-column Derivatization and Fluorometric Detection.
Anal Sci
May 2019
Faculty of Pharmaceutical Sciences, Ritsumeikan University.
An analytical method for the determination of sialic acids in biological samples has been developed and applied to fetal bovine serum (FBS), newborn calf serum and adult bovine serum. The hydrolysis of sera was carried out and the liberated sialic acids were quantified using a rapid and sensitive HPLC. The HPLC includes the separation and detection of N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) using hydrophilic interaction liquid chromatography and a fluorometric post-column reaction with 2-cyanoacetamide.
View Article and Find Full Text PDFPlackett-Burman and Box-Behnken designs as chemometric tools for micro-determination of l-Ornithine.
Spectrochim Acta A Mol Biomol Spectrosc
March 2018
Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, Doha 2713, Qatar.
Plackett-Burman (PB) and Box-Behnken (BB) screening and response surface factorial designs were used to evaluate spectrophotometric and spectrofluorimetric approaches for the determination of l-Ornithine (ORN) as per se and in dietary supplements. Both approaches were based on the derivatization of the primary amino group of ORN via Hantzsch condensation reaction producing yellow coloured adducts (dihydrolutidine derivative). The reaction product was determined spectrophotometrically (method A) at λ=327nm and spectrofluorimetrically (method B) at 480nm (λ) after excitation at 325nm (λ).
View Article and Find Full Text PDFA modified FOX-1 method for Micro-determination of hydrogen peroxide in honey samples.
Food Chem
December 2017
Department of Food Science and Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China. Electronic address:
Hydrogen peroxide (HO) is a major antibacterial activity-associated biomarker in honey. Measurement of endogenous HO in honey is of great value in prediction of the HO-depended antibacterial activity and characterization or selection of honey samples for their use as an antibacterial agent or natural food preservative. Considering current methods for HO determination are either time-consuming or complicated with their high-cost, a study was conducted to modify and validate the spectrophotometry-based ferrous oxidation-xylenol orange (FOX-1) method for micro-determination of HO in honey samples.
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