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Safety of immune checkpoint inhibitors in patients with cancer and pre-existing autoimmune disease.
Ann Transl Med
June 2021
Division of Rheumatology, University of Washington, Seattle, WA, USA.
Background: Patients with pre-existing autoimmune disease (AD) have been largely excluded from clinical trials of immune checkpoint inhibitors (ICI), so data on safety of ICIs among patients with pre-existing AD are relatively limited. There is a need for deeper understanding of the type and management of complications from ICI in patients with pre-existing AD. We sought to investigate the safety of ICIs in patients with pre-existing ADs as well as factors associated with AD flare.
View Article and Find Full Text PDFThe development of autoimmune inflammatory arthropathy in mice transgenic for the human T cell leukemia virus type-1 env-pX region is not dependent on H-2 haplotypes and modified by the expression levels of Fas antigen.
J Immunol
December 1998
Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan.
Previously, we reported that human T cell leukemia virus type-1 env-pX region-introduced transgenic (pX-Tg) mice develop an inflammatory polyarthropathy. Although autoimmune pathogenesis was suggested, the detailed mechanisms remain to be elucidated. In this report, we examined effects of the MHC and fas genes on the development of the disease.
View Article and Find Full Text PDFPrognostic criteria in rheumatoid arthritis: can we predict which patients will require specific anti-rheumatoid treatment?
Clin Exp Rheumatol
October 1997
Rheumatology Unit, Bristol University Division of Medicine, Bristol Royal Infirmary, UK.
Unlabelled: Longitudinal studies of rheumatoid arthritis (RA) have shown that joint damage often occurs early in the disease. Therefore, the early treatment of RA with "disease modifying" drugs is gaining acceptance. However, many patients presenting with inflammatory polyarthropathy will follow a benign course.
View Article and Find Full Text PDFLong-term results of total arthroplasty in adolescents with debilitating polyarthropathy.
Clin Orthop Relat Res
October 1992
Department of Orthopedic Surgery, Baylor College of Medicine, Houston, Texas 77030.
The authors retrospectively reviewed 29 hip and 13 knee arthroplasties performed in 17 adolescents and young adults from 1973 through 1979. Most patients had severe multiple joint involvement; 16 had juvenile rheumatoid arthritis. Clinical and roentgenographic evaluations were performed before operation and at routine intervals for up to 11 years after operation.
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