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Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patient.
Mult Scler Relat Disord
September 2019
Department of Neurosciences, Division of Neurology, Geneva University Hospital, Geneva, Switzerland; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address:
Background: Fingolimod is the first approved oral disease-modifying treatment for relapsing-remitting multiple sclerosis. Fingolimod targets lymphocytes, exerting a modulator effect on cell-surface sphingosine-1-phosphate receptors and thus blocking lymphocytes egression from secondary lymphoid organs. Recent reports describe fingolimod cessation being followed by severe or pseudo-tumoral relapse, but it usually does not happen on continuous long-term treatment.
View Article and Find Full Text PDFLymphoproliferative disorders in children with primary immunodeficiencies: immunological status may be more predictive of the outcome than other criteria.
Histopathology
February 2001
Service d'Anatomie-Pathologique, Hôpital Necker-Enfants Malades, Paris, France.
Aims: Lymphoproliferative disorders (LPDs) are a severe complication in primary immunodeficiency and post-transplant patients. In primary immunodeficiency patients, LPDs are not well-known and, thus, we tried to evaluate their distinctive features and to determine prognostic factors predictive of clinical outcome by comparison with LPDs in post-transplant children.
Methods And Results: Clinical records and histopathology of 18 LPDs occurring in primary immunodeficieny children were compared with those of 10 LPDs in post-transplant children, together with results of in-situ hybridization for the detection of Epstein-Barr virus (EBV)-RNA and molecular biological techniques.
[Mediastinal adenopathy disclosing Castleman's disease. Apropos of a case].
Rev Mal Respir
June 1991
Service de Pneumologie et Immuno-allergologie, Hôpital A.-Calmette, Lille.
Castleman's disease or pseudo-tumoral lymphoid hyperplasia is a rare entity. We report a case of Castleman's tumour in the antero-superior mediastinum which was revealed by a radiological examination in a young woman of 26. We also report immunohistochemical studies.
View Article and Find Full Text PDFThe association of adenopathies, having sometimes a tumoral aspect, and a polyclonal hypergammaglobulinemia in the blood can be observed in various illnesses. In all these diseases the increase in the volume of the lymph nodes is partly due to the hyperplasia of the lymphoid B regions. Lymph node biopsy allows a precise diagnosis to be made, providing a thorough analytical study of the histopathological lesions is performed.
View Article and Find Full Text PDFThe authors report one case of sinus histiocytosis with massive lymphadenopathy which occurred in a 70 years old woman. They remind the main features of this pseudolymphomatous benign disorder with three key microscopic findings : massive sinus histiocytosis, lymphophagocytosis, proliferation of mature plasma cells. There is no effective therapy and nothing definite about the etiology.
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