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Molecular Characterization of Aminoglycoside-modifying Enzymes (AMEs)in Aminoglycoside-Resistant : A Cross-sectional Study in Northeastern Iran.
Iran J Pathol
January 2025
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Background & Objective: The resistance genes encoding aminoglycoside-modifying enzymes (AMEs) are now widely prevalent in different populations of . The study aimed to determine the frequency of AMEs-encoding genes in clinical isolates of .
Methods: A total of 105 isolates were obtained from the different clinical samples; and then were identified by conventional biochemical tests.
Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates.
NPJ Biofilms Microbiomes
March 2025
Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
Cyclic diguanylate (c-di-GMP) is a central biofilm regulator in Pseudomonas aeruginosa, where increased intracellular levels promote biofilm formation and antibiotic tolerance. Targeting the c-di-GMP network may be a promising anti-biofilm approach, but most strategies studied so far aimed at eliminating surface-attached biofilms, while in vivo P. aeruginosa biofilms often occur as suspended aggregates.
View Article and Find Full Text PDFCharacteristic profiles of molecular types, antibiotic resistance, antibiotic resistance genes, and virulence genes of isolates from caprine mastitis in China.
Front Cell Infect Microbiol
March 2025
Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Henan Provincial Engineering Laboratory of Insects Bio-reactor, Nanyang Normal University, Nanyang, China.
is a significant pathogen in dairy animals, particularly when it infects the mammary gland; however, its prevalence among dairy goats in China remains poorly understood. This study aimed to investigate the distribution and characteristics of isolates in dairy goats across China. A total of 515 milk samples were collected from goats diagnosed with mastitis in 14 provinces.
View Article and Find Full Text PDFClinical Efficacy of Tobramycin Dexamethasone+Pranoprofen Eye Drops on Endophthalmitis in Cataract Patients Complicated with Diabetes Mellitus after Intraocular Lens Implantation.
Niger J Clin Pract
December 2024
Deparement of Ophthalmology, Huai'an Hospital, Huai'an, Jiangsu, China.
Background: There is little research on the anti-inflammatory efficacy and safety of tobramycin dexamethasone+pranoprofen eye drops in treating endophthalmitis.
Aim: To appraise the efficacy and safety of tobramycin dexamethasone+propranolofen eye drops in the treatment of endophthalmitis.
Methods: The degree of corneal edema, foveal thickness, score of anterior chamber (AC) flares, best corrected visual acuity (BCVA), fasting blood glucose, inflammatory indexes of serum and aqueous humor, and adverse reactions were observed every week.
Evaluation of aminoglycoside- and methicillin-resistant Staphylococcus aureus: phenotypic and genotypic insights from clinical specimens in Ardabil, Iran.
BMC Infect Dis
February 2025
Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Background: Combination therapy including an aminoglycoside antibiotic and a cell-wall active agent is considered the most suitable option to treat invasive infections with methicillin-resistant Staphylococcus aureus (MRSA). Dual drug therapy enhances the effectiveness of treatment and reduces the risk of resistance development. This study aims to elucidate the phenotypic and molecular resistance to aminoglycosides and methicillin, and the molecular epidemiologic characteristics of S.
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