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What is the origin of the normal ranges of blood cell counts? An evolutionary perspective.
EJHaem
February 2025
Centre International de Recherche en Infectiologie (CIRI, INSERM U1111, CNRS UMR 5308, École Normale supérieure de Lyon) Lymphoma ImmunoBiology team Faculté de Médecine Lyon sud Université Claude Bernard Lyon 1 Lyon France.
Background: The normal values of the complete blood count are part of the foundational medical knowledge that is seldom questioned due to their well-established nature. These normal values are critical for optimal physiological function while minimizing the harmful consequences of an excessive number of blood cells. Thus, they represent an evolutionary trade-off likely shaped by natural selection if they significantly influence individual fitness and exhibit heritability.
View Article and Find Full Text PDFRETROSPECTIVE OBSERVATIONAL STUDY OF VITAMIN D STATUS IN NEUROLOGICAL PATIENTS.
Acta Clin Croat
December 2023
Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
The main objective of this study was to investigate the prevalence of insufficient serum 25-hydroxyvitamin D level in a sample of neurological patients and to compare it to the estimate in the general Croatian population. The secondary aim was to test for the possible significant differences in vitamin D2 insufficiency between the groups of patients according to gender, season, region, vitamin D3 supplementation, and diagnosis of autoimmune disease. This retrospective study involved 371 neurological patients in one-year period.
View Article and Find Full Text PDFSHOULD AN ACCESSORY RENAL ARTERY BE CONSIDERED AS A CAUSE OF HYPERTENSION IN ADOLESCENTS: A CASE REPORT.
Acta Clin Croat
December 2023
Department of Internal Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
The role of an accessory renal artery in the pathogenesis of hypertension is still controversial. In this report, we describe a previously healthy 16-year-old girl with an accessory right renal artery who presented with hypertensive urgency (no progressive target organ dysfunction). Initial workup other than hypercholesterolemia and mild proteinuria was normal with no signs of other target organ damage.
View Article and Find Full Text PDFURINARY NEPHRIN AS AN EARLY BIOMARKER OF HYPERTENSIVE NEPHROPATHY.
Acta Clin Croat
December 2023
Department of Digestive Surgery, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, North Macedonia.
Hypertensive nephropathy (HN) is characterized by kidney damage due to chronic high blood pressure. Podocytes play a crucial role in the pathogenesis of HN, thus, nephrin could be important in the early diagnosis of HN. The aim of the study was to investigate the association of urinary nephrin (u-nephrin) levels with clinical and laboratory characteristics in patients with HN and to test diagnostic relevance of u-nephrin as an early biomarker of HN.
View Article and Find Full Text PDFASPARTATE AMINOTRANSFERASE AND GAMMA-GLUTAMYL TRANSFERASE: INTRIGUING CLINICAL BIOMARKERS IN DISCRIMINATION OF HEPATIC LESION BETWEEN HEPATITIS C INFECTED PATIENTS AND HEALTHY CONTROLS.
Acta Clin Croat
December 2023
Bitola Clinical Hospital, Department of Internal Medicine, Bitola, North Macedonia.
Over 1.5 million new cases of chronic hepatitis C virus (HCV) infection occur each year, infecting an estimated 58 million people worldwide. We aimed to find differences in peripheral blood count, liver enzymes and degradation products between HCV infected and healthy controls, and their impact on detection of the disease and discrimination of the diseased from non-diseased subjects.
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