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The role of prescribed controlled substance acquisition as potential triggers of opioid overdose: A case-crossover study.
Int J Drug Policy
December 2024
Division of Pharmaceutical Evaluation and Policy, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR, 72205, USA. Electronic address:
Background: The role of prescribed opioids and benzodiazepines as risk factors for opioid overdose are well established, however, their role as potential 'triggers' of opioid overdose has not been formally investigated.
Objective: The objective of this study was to evaluate the temporal relationship between controlled substance acquisition and opioid overdose utilizing a case-crossover design.
Methods: This study utilized Arkansas statewide data between 2014 and 2020.
Early Drug Prescription Patterns as Predictors of Final Workers Compensation Claim Costs and Closure: An Updated Analysis on an Expanded Cohort.
J Occup Environ Med
December 2022
From the Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland (Dr Tao, Dr Lavin, Mr Yuspeh, Dr Tsourmas, Dr Kalia, Dr Leung, Dr Green-McKenzie, Dr Bernacki); Strategy, Enterprise Risk, and Research, Louisiana Workers' Compensation Corporation, Baton Rouge, Louisiana (Mr Yuspeh); Texas Mutual, Workers' Compensation Insurance, Austin, Texas (Dr Leung, Dr Tsourmas, Dr Williams); General Electric, Norwalk, Connecticut (Dr Kalia); Corporate Administration Office, AF Group, Lansing, Michigan (Dr Hunt); Department of Population Health, Dell Medical School, the University of Texas at Austin, Austin, Texas (Dr Tao, Dr Leung, Dr Tsourmas, Dr Bernacki).
Objective: The aim of the study is to determine the associations of workers' compensation claim costs and return to work with drugs prescribed for early symptom management.
Methods: Claims filed from 1998 to 2007 were followed for 10 years from the injury date. Drugs analyzed included gabapentin, pregabalin, antipsychotics, antidepressants, sedatives, benzodiazepines, carisoprodol, and opioids, controlling for initial reserve, sex, age, physical therapy, attorney involvement, and surgery.
Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.
Neurology
September 2022
From the Division of Pharmacoepidemiology and Pharmacoeconomics (N.F.K., K.B., R.J.G., S.M.V.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Department of Epidemiology (N.F.K., J.J.G.), Harvard T.H. Chan School of Public Health; Department of Health Policy and Management (M.L.B.), Harvard T.H. Chan School of Public Health; Division of General Internal Medicine and Primary Care (M.L.B.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and Department of Biostatistics (R.J.G.), Harvard T.H. Chan School of Public Health, Boston, MA.
Background And Objectives: The concomitant use of prescription opioids and skeletal muscle relaxants has been associated with opioid overdose, but little data exist on the head-to-head safety of these drug combinations. The objective of this study was to compare the risk of opioid overdose among patients on long-term opioid therapy who concurrently initiate skeletal muscle relaxants.
Methods: We conducted an active comparator cohort study spanning 2000 to 2019 using healthcare utilization data from 4 US commercial and public insurance databases.
Pharmacotherapy for Spine-Related Pain in Older Adults.
Drugs Aging
July 2022
Department of Neurology, Boston University School of Medicine, Boston Medical Center, 85 E. Concord St, 1122, Boston, MA, 02118, USA.
Article Synopsis
- As the aging population experiences more spine-related pain, managing it with medications is complicated for older adults due to health issues and interactions with multiple drugs.* -
- A review of 138 clinical trials focused on the effectiveness and safety of various medications such as NSAIDs, gabapentin, SNRIs, and tramadol specifically for individuals over 65.* -
- The findings suggest that NSAIDs are effective with precautions, while gabapentin shows mixed results, and SNRIs are preferred for neuropathic pain, highlighting the need for tailored treatment strategies for older patients.*
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