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Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes.
PLoS Negl Trop Dis
October 2024
Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Background: Auranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi. The auranofin activity against Histoplasma capsulatum, the dimorphic fungus that causes histoplasmosis, has not been properly addressed. Since there are few therapeutic options for this life-threatening systemic mycosis, this study evaluated the effects of auranofin on H.
View Article and Find Full Text PDFFatal misdiagnosis of progressive disseminated histoplasmosis.
Med Mycol Case Rep
September 2024
Laboratory of Histology and Embryology, Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
Article Synopsis
- Disseminated histoplasmosis is a fungal infection that primarily affects people with weakened immune systems and often presents with vague symptoms.
- In regions where this disease is not commonly considered, delays in diagnosis and treatment can result in serious health complications.
- The article discusses a case of a Greek farmer with a healthy immune system who was misdiagnosed, leading to insufficient treatment and ultimately his death.
Antifungal efficacy and immunomodulatory effect of PLGA nanoparticle-encapsulated itraconazole in histoplasmosis in vivo model.
J Mycol Med
September 2024
Experimental and Medical Micology Group, Corporación para Investigaciones Biológicas (CIB), UdeA, UPB, UdeS, Cra 72A #78b-141, Altamira, Medellin 050036, Colombia; School of Health Sciences, Universidad Pontificia Bolivariana, Cl. 78b #72A - 109, Medellín 050036, Colombia. Electronic address:
Introduction: Histoplasma capsulatum is the etiological agent of histoplasmosis, the most common endemic pulmonary mycosis. Itraconazole (ITZ) is the choice for mild disease and a step-down therapy in severe and disseminated clinical presentations. Drug encapsulation into nanoparticles (NPs) is an alternative to improve drug solubility and bioavailability, reducing undesirable interactions and drug degradation and reaching the specific therapeutic target with lower doses.
View Article and Find Full Text PDFA recombinant chimeric antigen constructed with B-cell epitopes from Mycobacterium leprae hypothetical proteins is effective for the diagnosis of leprosy.
Diagn Microbiol Infect Dis
July 2024
Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil.
The diagnosis if leprosy is difficult, as it requires clinical expertise and sensitive laboratory tests. In this study, we develop a serological test for leprosy by using bioinformatics tools to identify specific B-cell epitopes from Mycobacterium leprae hypothetical proteins, which were used to construct a recombinant chimeric protein, M1. The synthetic peptides were obtained and showed good reactivity to detect leprosy patients, although the M1 chimera have showed sensitivity (Se) and specificity (Sp) values higher than 90.
View Article and Find Full Text PDFClosing the Gap in Proteomic Identification of : A Case Report and Review of Literature.
J Fungi (Basel)
October 2023
Department of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Histoplasmosis is a globally distributed systemic infection caused by the dimorphic fungus (). This fungus can cause a wide spectrum of clinical manifestations, and the diagnosis of progressive disseminated histoplasmosis is often a challenge for clinicians. Although microscopy and culture remain the gold standard diagnostic tests for identification, matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) has emerged as a method of microbial identification suitable for the confirmation of dimorphic fungi.
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